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Dementia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>TAR DNA\u2010binding protein 43 (TDP\u201043) is a highly prevalent proteinopathy that is involved in neurodegenerative processes, including axonal damage. To date, no ante mortem biomarkers exist for TDP\u201043, and few studies have directly assessed its impact on neuroimaging measures utilizing pathologic quantification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Ante mortem diffusion\u2010weighted images were obtained from community\u2010dwelling older adults. Regression models calculated the relationship between\n                      <jats:italic>post mortem<\/jats:italic>\n                      TDP\u201043 burden and ante mortem fractional anisotropy (FA) within each voxel in connection with the hippocampus, controlling for coexisting Alzheimer's disease and demographics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Results revealed a significant negative relationship (false discovery rate [FDR] corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) between\n                      <jats:italic>post mortem<\/jats:italic>\n                      TDP\u201043 and ante mortem FA in one cluster within the left medial temporal lobe connecting to the parahippocampal cortex, entorhinal cortex, and cingulate, aligning with the ventral subdivision of the cingulum. FA within this cluster was associated with cognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Greater TDP\u201043 burden is associated with lower FA within the limbic system, which may contribute to impairment in learning and memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:italic>Post mortem<\/jats:italic>\n                            TDP\u201043 pathological burden is associated with reduced ante mortem fractional anisotropy.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Reduced FA located in the parahippocampal portion of the cingulum.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>FA in this area was associated with reduced episodic and semantic memory.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>FA in this area was associated with increased inward hippocampal surface deformation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13808","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T01:13:03Z","timestamp":1718413983000},"page":"4401-4410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In vivo effect of LATE\u2010NC on integrity 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