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Dementia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We evaluated associations between plasma and neuroimaging\u2010derived biomarkers of Alzheimer's disease and related dementias and the impact of health\u2010related comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We examined plasma biomarkers (neurofilament light chain, glial fibrillary acidic protein, amyloid beta [A\u03b2] 42\/40, phosphorylated tau 181) and neuroimaging measures of amyloid deposition (A\u03b2\u2010positron emission tomography [PET]), total brain volume, white matter hyperintensity volume, diffusion\u2010weighted fractional anisotropy, and neurite orientation dispersion and density imaging free water. Participants were adjudicated as cognitively unimpaired (CU;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0299), mild cognitive impairment (MCI;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0192), or dementia (DEM;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a065). Biomarkers were compared across groups stratified by diagnosis, sex, race, and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carrier status. General linear models examined plasma\u2010imaging associations before and after adjusting for demographics (age, sex, race, education),\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 status, medications, diagnosis, and other factors (estimated glomerular filtration rate [eGFR], body mass index [BMI]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Plasma biomarkers differed across diagnostic groups (DEM\u00a0&gt;\u00a0MCI\u00a0&gt;\u00a0CU), were altered in A\u03b2\u2010PET\u2010positive individuals, and were associated with poorer brain health and kidney function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>eGFR and BMI did not substantially impact associations between plasma and neuroimaging biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma biomarkers differ across diagnostic groups (DEM\u00a0&gt;\u00a0MCI\u00a0&gt;\u00a0CU) and are altered in A\u03b2\u2010PET\u2010positive individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Altered plasma biomarker levels are associated with poorer brain health and kidney function.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma and neuroimaging biomarker associations are largely independent of comorbidities.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n    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