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The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high\u2010income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC\u2010focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations. Development of effective preventive, diagnostic, and therapeutic approaches for dementia in LMICs requires targeted, personalized, and harmonized efforts. Our article represents timely discussions at the 2022 Symposium on Dementia and Brain Aging in LMICs that identified the foremost opportunities to advance dementia research, differential diagnosis, use of neuropsychometric tools, awareness, and treatment options. We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Two\u2010thirds of persons with dementia live in LMICs, yet research and costs are skewed toward HICs.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>LMICs expect dementia prevalence to more than double, accompanied by socioeconomic disparities.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The 2022 Symposium on Dementia in LMICs addressed advances in research, diagnosis, prevention, and policy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The Nairobi Declaration urges global action to enhance dementia outcomes in LMICs.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13836","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:00:37Z","timestamp":1714651237000},"page":"4290-4314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["The 2022 symposium on dementia and brain aging in low\u2010 and middle\u2010income countries: Highlights on research, diagnosis, care, and impact"],"prefix":"10.1002","volume":"20","author":[{"given":"Raj","family":"Kalaria","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Maestre","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience and Human Genetics University of Texas Rio Grande Valley One W. University Blvd  Brownsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-7130","authenticated-orcid":false,"given":"Simin","family":"Mahinrad","sequence":"additional","affiliation":[{"name":"Division of Medical and Scientific Relations Alzheimer's Association  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy M.","family":"Acosta","sequence":"additional","affiliation":[{"name":"Universidad Nacional Pedro Henriquez Urena (UNPHU)  Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus Olusola","family":"Akinyemi","sequence":"additional","affiliation":[{"name":"Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training College of Medicine University of Ibadan  Ibadan Oyo 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