{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:33:53Z","timestamp":1792190033215,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22de0107002"],"award-info":[{"award-number":["JP22de0107002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ae0101077"],"award-info":[{"award-number":["JP23ae0101077"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23dk0207052"],"award-info":[{"award-number":["JP23dk0207052"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Participants aged 65\u201085 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 531 participants, 406 completed the trial. The between\u2010group difference in composite score changes was 0.047 (95% CI: \u22120.029 to 0.124). Secondary analyses indicated positive impacts of interventions on several secondary health outcomes. The interventions appeared to be particularly effective for individuals with high attendance during exercise sessions and those with the apolipoprotein E \u03b54 allele and elevated plasma glial fibrillary acidic protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The multidomain intervention showed no efficacy in preventing cognitive decline. Further research on more efficient strategies and suitable target populations is required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>This trial evaluated the efficacy of multidomain intervention in individuals with MCI.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The trial did not show a significant difference in preplanned cognitive outcomes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Interventions had positive effects on a wide range of secondary health outcomes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Those with adequate adherence or high risk of dementia benefited from interventions.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13838","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T04:59:50Z","timestamp":1713761990000},"page":"3918-3930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Japan\u2010Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2369-3095","authenticated-orcid":false,"given":"Takashi","family":"Sakurai","sequence":"first","affiliation":[{"name":"Research Institute National Center for Geriatrics and Gerontology Obu Aichi Japan"},{"name":"Department of Prevention and Care Science Research Institute National Center for Geriatrics and Gerontology Obu Aichi Japan"},{"name":"Department of Cognition and Behavior Science Nagoya University Graduate School of Medicine 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