{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:48:19Z","timestamp":1791996499826,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501200"],"award-info":[{"award-number":["2021YFC2501200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Platelets serve as the primary peripheral reservoir of amyloid beta (A\u03b2). However, there is limited research on platelet markers in routine blood examinations, particularly with regard to the large platelet ratio (P\u2010LCR) in Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study included 512 AD patients and 205 healthy controls (HCs). Platelet markers and apolipoprotein E (<jats:italic>APOE<\/jats:italic>) 4 status were assessed in all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The study revealed that P\u2010LCR was significantly elevated in AD patients compared to HCs. In AD patients carrying <jats:italic>APOE<\/jats:italic>4, P\u2010LCR significantly negatively correlated with Montreal Cognitive Assessment scores. There was an observed increasing trend in the rate of change in P\u2010LCR with disease progression. Binary logistic regression analysis indicated that P\u2010LCR may constitute a risk factor for AD, after adjusting for age, sex, <jats:italic>APOE<\/jats:italic>4, and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>P\u2010LCR is associated with disease severity in AD patients carrying <jats:italic>APOE<\/jats:italic>4. P\u2010LCR may be a promising marker to reflect platelet activity in AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>P\u2010LCR significantly negatively correlated with MoCA scores in AD patients with <jats:italic>APOE<\/jats:italic>4.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The rate of change in P\u2010LCR showed an increasing trend with disease progression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>P\u2010LCR may be a risk factor for AD.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13841","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T13:29:29Z","timestamp":1715088569000},"page":"4366-4372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Correlation analysis of peripheral platelet markers and disease phenotypes in Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Jiajia","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Rare disease center West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Laboratory of Neurodegenerative Disorders West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Rare disease center West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Laboratory of Neurodegenerative Disorders West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7404","authenticated-orcid":false,"given":"Xueping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Rare disease center West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Laboratory of Neurodegenerative Disorders West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Rare disease center West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Laboratory of Neurodegenerative Disorders West China Hospital Sichuan University  Chengdu Sichuan 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