{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:00:16Z","timestamp":1792119616951,"version":"4.4.0"},"reference-count":272,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019\u2010111514RA\u2010I00"],"award-info":[{"award-number":["PID2019\u2010111514RA\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG2019\u2010AARG\u2010644641"],"award-info":[{"award-number":["AARG2019\u2010AARG\u2010644641"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG2019\u2010AARG\u2010644641\u2010RAPID"],"award-info":[{"award-number":["AARG2019\u2010AARG\u2010644641\u2010RAPID"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG072475"],"award-info":[{"award-number":["R01AG072475"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R56AG082414"],"award-info":[{"award-number":["R56AG082414"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Sex and gender\u2014biological and social constructs\u2014significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular disease) which ultimately shape cognitive trajectories. Understanding the interplay of these factors is central to understanding resilience\u00a0and resistance mechanisms\u00a0explaining maintained cognitive function and\u00a0reduced pathology accumulation in aging and AD.\u00a0In this narrative review, the ADDRESS! Special Interest Group (Alzheimer's Association) adopted a multidisciplinary approach to provide the foundations and recommendations for future research into sex\u2010 and gender\u2010specific drivers of resilience, including a sex\/gender\u2010oriented review of risk factors, genetics, AD and non\u2010AD pathologies, brain structure and function, and animal research.\u00a0We urge the field to adopt a sex\/gender\u2010aware approach to resilience to advance our understanding of the intricate interplay of biological and social determinants and consider sex\/gender\u2010specific resilience throughout disease stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Sex differences in resilience to cognitive decline vary by age and cognitive status.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Initial evidence supports sex\u2010specific distinctions in brain pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings suggest sex differences in the impact of pathology on cognition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>There is a sex\u2010specific change in resilience in the transition to clinical stages.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Gender and sex factors warrant study: modifiable, immune, inflammatory, and vascular.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13844","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T07:00:35Z","timestamp":1720162835000},"page":"5695-5719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":234,"title":["Sex and gender differences in cognitive resilience to aging and Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Eider M.","family":"Arenaza\u2010Urquijo","sequence":"first","affiliation":[{"name":"Environment and Health Over the Life Course Programme, Climate, Air Pollution, Nature and Urban Health Programme Barcelona Institute for Global Health (ISGlobal)  Barcelona Spain"},{"name":"University of Pompeu Fabra Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Boyle","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts 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