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Linear regression models with cognition as outcome were used. We also tested whether amyloid beta (A\u03b2) status modified these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher baseline CSF sTREM2 was associated with a positive global cognition (Preclinical Alzheimer's Cognitive Composite) rate of change, and better memory and executive outcomes, independently of AD pathology. Higher baseline plasma GFAP was associated with a decline on attention rate of change. Stratified analyses by A\u03b2 status showed that CSF sTREM2 and YKL\u201040 were positively associated with executive functioning in amyloid negative (A\u03b2\u2212) individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our results suggest that a TREM2\u2010mediated microglial response may be associated with better longitudinal cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Higher cerebrospinal fluid (CSF) soluble triggering receptor expressed on myeloid cell 2 (sTREM2) relates to better longitudinal cognitive performance.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The association between CSF sTREM2 and cognition is independent of Alzheimer's disease (AD) pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Targeting microglial reactivity may be a therapeutic strategy\u00a0for AD prevention.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13862","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T02:34:38Z","timestamp":1721442878000},"page":"5819-5832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's 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