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Furthermore, ancestral background may significantly impact the link between <jats:italic>APOE<\/jats:italic> and AD, underscoring the need for more inclusive research.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In 2023, the Alzheimer's Association convened multidisciplinary researchers at the \u201cAAIC Advancements: APOE\u201d conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE\u2010targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Understanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>APOE is a central player in the pathogenesis of Alzheimer's disease.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>APOE exerts a numerous effects throughout the brain on amyloid\u2010beta, tau, and other pathways.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13877","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T12:06:53Z","timestamp":1721390813000},"page":"6590-6605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference"],"prefix":"10.1002","volume":"20","author":[{"given":"Courtney M.","family":"Kloske","sequence":"first","affiliation":[{"name":"Alzheimer's Association  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Belloy","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University, Stanford  Palo Alto California USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine, St. Louis, Missouri  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Blue","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Medicine University of Washington  Seattle Washington USA"},{"name":"Institute for Public Health Genetics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Bowman","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry &amp; Biophysics and Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Alzheimer's Association  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Hope Center for Neurological Disorders Knight Alzheimer's Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornit","family":"Chiba\u2010Falek","sequence":"additional","affiliation":[{"name":"Division of Translational Brain Sciences Department of Neurology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Neurology Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert Di","family":"Paolo","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc.  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