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This failing translation from observational to interventional research may result from overlooking nutrient interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We developed a nutrient status index capturing the number of suboptimal statuses of omega\u20103 fatty acids, homocysteine, and vitamin D (range 0 to 3). We associated this index with dementia incidence in a subsample (age \u2265 50 years) of the Framingham Heart Study Offspring cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 968 participants, 79 developed dementia over 15.5 years (median follow\u2010up). Each point increase in nutrient status index was associated with a 50% higher risk of dementia (hazard ratio [HR]\u00a0=\u00a01.50; 95% confidence interval [CI]\u00a0=\u00a01.16, 1.96). Participants with three high\u2010risk statuses had a four\u2010fold increased risk of dementia compared to participants without high\u2010risk status (HR\u00a0=\u00a04.68; 95% CI\u00a0=\u00a01.69, 12.94).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Concurrent nutrient deficiencies are associated with the risk of dementia. The potential of optimizing nutritional status to lower dementia risk warrants further study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Nutrition and dementia research calls for multiple\u2010nutrient approaches.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We studied combined suboptimal statuses of omega\u20103 polyunsaturated fatty acids, homocysteine, and vitamin D.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Suboptimal status of the three nutrients was associated with dementia risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The risk estimate was larger than for other factors (ie, diabetes, apolipoprotein E\u00a0\u03b54 carrier).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Future studies should assess the effect of improving nutrient status on dementia risk.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13884","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:35:20Z","timestamp":1718199320000},"page":"4594-4601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Concurrent nutrient deficiencies are associated with dementia incidence"],"prefix":"10.1002","volume":"20","author":[{"given":"Annick P. 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Neurodegenerative Diseases UT Health San Antonio  San Antonio Texas USA"},{"name":"Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"The Framingham Heart Study  Framingham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondine","family":"van de Rest","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University &amp; Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Dementia: a public health priority.World Health Organization;2019."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30338\u20107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(22)00120\u20109"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.383"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012244"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.11.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010215011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.41.3.279"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20107435(75)90037\u20107"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20104347(87)80438\u20103"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.706127"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318249f6a9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.08.016"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.3.925s"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102891\u201013\u201030"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504327"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520100096046"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1979.03630450011006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_8_22_1","unstructured":"R Core Team.R: A language and enironment for statistical computing.R Foundation for Statistical Computing.https:\/\/www.R\u2010project.org\/"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170732"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010023\u201003900\u20107"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471\u2010023\u201001759\u20102"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13058"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00052"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010071715\u2010050947"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.08.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010022\u201002924\u2010w"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150777"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.103283"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010181148"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4899"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00295"}],"container-title":["Alzheimer's &amp; 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