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CL equations for FBB were derived using standard methods, using FBB data collected between 90 and 110 min with paired Pittsburgh compound B data. Linear mixed models and <jats:italic>t<\/jats:italic>\u2010tests evaluated the impact of acquisition time on CL increases.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>CL values increased significantly over the scan using the whole cerebellum, cerebellar gray matter, and brainstem as reference regions, particularly in amyloid\u2010positive individuals. In contrast, CLs based on white matter\u2013containing reference regions decreased across the scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The quantification of CLs in FBB PET imaging is influenced by both the overall scan acquisition time and the choice of reference region. Standardized acquisition protocols or the application of acquisition time\u2013specific CL equations should be implemented in clinical protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Acquisition timing affects florbetaben positron emission tomography (PET) scan quantification, especially in amyloid\u2010positive participants.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The impact of acquisition timing on quantification varies across common reference regions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Consistent acquisitions and\/or appropriate post\u2010injection adjustments are needed to ensure comparability of PET data.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13893","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T04:55:20Z","timestamp":1720068920000},"page":"5299-5310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-8272","authenticated-orcid":false,"given":"Emily","family":"Johns","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary A.","family":"Vossler","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University School of Medicine  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