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A triggering factor may be the interaction of vascular dysfunction and tau pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We imaged\n                      <jats:italic>post mortem<\/jats:italic>\n                      human tissue at 100 \u03bcm\n                      <jats:sup>3<\/jats:sup>\n                      with 7 T magnetic resonance imaging and manually labeled individual blood vessels (mean\u00a0=\u00a0270 slices\/case). Vessel density was quantified and compared per\u00a0EC subfield, between EC and PC, and in relation to tau and TAR DNA\u2010binding protein 43 (TDP\u201043) semiquantitative scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>PC was more vascularized than EC and vessel densities were higher in posterior EC subfields. Tau and TDP\u201043 strongly correlated with vasculature density and subregions with severe tau at the preclinical stage had significantly greater vessel density than those with low tau burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These data impact cerebrovascular maps, quantification of subfield vasculature, and correlation of vasculature and pathology at early stages. The ordered association of vessel density, and tau or TDP\u201043 pathology, may be exploited in a predictive context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Vessel density correlates with phosphorylated tau (p\u2010tau) burden in entorhinal and perirhinal cortices.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Perirhinal area 35 and posterior entorhinal cortex showed greatest p\u2010tau burden but also the highest vessel density in the preclinical phase of Alzheimer's disease.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We combined an ex vivo magnetic resonance imaging model and histopathology to demonstrate the 3D reconstruction of intracortical vessels and its spatial relationship to the pathology.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13896","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:45:07Z","timestamp":1718412307000},"page":"4649-4662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Entorhinal vessel density correlates with phosphorylated tau and TDP\u201043 pathology"],"prefix":"10.1002","volume":"20","author":[{"given":"Josu\u00e9","family":"Llamas Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 J. W.","family":"van der Kouwe","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Oltmer","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Department of Digital Health &amp; Innovation Vivantes Netzwerk f\u00fcr Gesundheit GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Rosenblum","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Mercaldo","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"MGH Institute for Technology Assessment Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Fischl","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Computer Science and Artificial Intelligence Laboratory (CSAIL) Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Marshall","sequence":"additional","affiliation":[{"name":"C.S. Kubik Laboratory for Neuropathology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[{"name":"C.S. Kubik Laboratory for Neuropathology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-6671","authenticated-orcid":false,"given":"Jean C.","family":"Augustinack","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. 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