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JPM is a statistical model that simultaneously models the relationships between head\u2010to\u2010head and anchor point data. JPM was compared to a linear regression approach analogous to the one used in the amyloid PET Centiloid scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A strong linear relationship was observed between CTR values across brain regions. Using the JPM approach, CTR estimates were similar to, but more accurate than, those derived using the linear regression approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Preliminary findings using the JPM support the development and adoption of a universal scale for tau\u2010PET quantification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Tested a novel joint propagation model (JPM) to harmonize quantification of tau PET.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Units of common scale are termed \u201cCenTauRs\u201d.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Tested a Centiloid\u2010like linear regression approach.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Using five cohorts with head\u2010to\u2010head tau PET, JPM outperformed linearregressionbased approach.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Strong linear relationship was observed between CenTauRs values across brain regions.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13908","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T06:47:04Z","timestamp":1721717224000},"page":"5833-5848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model"],"prefix":"10.1002","volume":"20","author":[{"given":"Antoine","family":"Leuzy","sequence":"first","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Critical Path for Alzheimer's Disease (CPAD) Consortium Critical Path Institute  Tucson Arizona USA"},{"name":"Enigma Biomedical Group Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Lau","family":"Raket","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Florey Department of Neuroscience University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Molecular Imaging &amp; Therapy Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Klein","sequence":"additional","affiliation":[{"name":"F. 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