{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:53:57Z","timestamp":1792198437792,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Blood\u2010based biomarkers are a cost\u2010effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation\u2010immunoassay (IP\u2010IA) as a test for predicting cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We measured levels of amyloid beta (A\u03b2)X\u201040 and A\u03b2X\u201042 in immunoprecipitated eluates from the DELCODE cohort. Receiver\u2010operating characteristic (ROC) curves, regression analyses, and Cox proportional hazard regression models were constructed to predict AP by A\u03b242\/40 classification in cerebrospinal fluid (CSF) and conversion to mild cognitive impairment (MCI) or dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We detected a significant correlation between A\u00dfX\u201042\/X\u201040 in plasma and CSF (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.473). Mixed\u2010modeling analysis revealed a substantial prediction of A\u00dfX\u201042\/X\u201040 with an area under the curve (AUC) of 0.81 for AP (sensitivity: 0.79, specificity: 0.74, positive predictive value [PPV]: 0.71, negative predictive value [NPV]: 0.81). In addition, lower A\u03b2X\u201042\/X\u201040 ratios were associated with negative PACC5 slopes, suggesting cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our results suggest that assessing the plasma A\u03b2X\u201042\/X\u201040 ratio via our semiautomated IP\u2010IA is a promising biomarker when examining patients with early or preclinical AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>New plasma A\u03b242\/A\u03b240 measurement using immunoprecipitation\u2013immunoassay<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma A\u03b242\/A\u03b240 associated with longitudinal cognitive decline<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Promising biomarker to detect subjective cognitive decline at\u2010risk for brain amyloid positivity<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13909","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T07:01:10Z","timestamp":1719558070000},"page":"5132-5142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Plasma amyloid beta X\u201042\/X\u201040 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9326-8193","authenticated-orcid":false,"given":"Jonathan","family":"Vogelgsang","sequence":"first","affiliation":[{"name":"Department of Psychiatry McLean Hospital, Harvard Medical School  Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Stark","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry University of Bonn Medical Center  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry University of Bonn Medical Center  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Klafki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Marcos","family":"Morgado","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Jahn\u2010Brodmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Schott","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Esselmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Bauer","sequence":"additional","affiliation":[{"name":"MicroDiscivery GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schuchhardt","sequence":"additional","affiliation":[{"name":"MicroDiscivery GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Kleineidam","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry University of Bonn Medical Center  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Wolfsgruber","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry University of Bonn Medical Center  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa\u2010Sophie","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Menne","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Predemtec AG, Rudower Chausee 29  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Priller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"School of Medicine Department of Psychiatry and Psychotherapy Technical University of Munich  Munich Germany"},{"name":"University of Edinburgh and UK DRI  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Spruth","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawek","family":"Altenstein","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Schneider","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry University of Bonn Medical Center  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Fliessbach","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry University of Bonn Medical Center  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Vogt","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Psychiatry University of Cologne, Medical Faculty  Cologne Germany"},{"name":"Excellence Cluster on Cellular Stress Response in Aging\u2010Associated Diseases (CECAD), University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayda","family":"Rostamzadeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cologne, Medical Faculty  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Duezel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research (IKND) Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzel","family":"Glanz","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enise","family":"Incesoy","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research (IKND) Otto\u2010von\u2010Guericke University  Magdeburg Germany"},{"name":"Department for Psychiatry and Psychotherapy University Clinic Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Butryn","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE, Munich)  Munich Germany"},{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Janowitz","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ewers","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE, Munich)  Munich Germany"},{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Perneczky","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE, Munich)  Munich Germany"},{"name":"Department of Psychiatry and Psychotherapy University Hospital, LMU Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) Munich  Munich Germany"},{"name":"Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, South Kensington  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Rauchmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Hospital, LMU Munich  Munich Germany"},{"name":"Sheffield Institute for Translational Neuroscience (SITraN) University of Sheffield, Broomhall  Sheffield UK"},{"name":"Department of Neuroradiology University Hospital LMU  Marchioninistrassee Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Guersel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Rostock Germany"},{"name":"Department of Psychosomatic Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Kilimann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Rostock Germany"},{"name":"Department of Psychosomatic Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Goerss","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Rostock Germany"},{"name":"Department of Psychosomatic Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Laske","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Tuebingen Germany"},{"name":"Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Munk","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Tuebingen Germany"},{"name":"Department of Psychiatry and Psychotherapy University of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Sanzenbacher","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Spottke","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurology University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Roy\u2010Kluth","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heneka","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg  Esch\u2010Belval Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Brosseron","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ramierez","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry University of Bonn Medical Center  Bonn Germany"},{"name":"Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"},{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Department of Psychiatry &amp; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmid","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Disorders (DZNE)  Bonn Germany"},{"name":"Institute for Medical Biometry University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen  Goettingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Goettingen Germany"},{"name":"Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED) Department of Medical Sciences University of Aveiro  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20102667(21)00249\u20108"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.952161"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(21)00066\u20101"},{"key":"e_1_2_8_6_1","unstructured":"CarrilloMC SnyderH AndrewsJS et\u00a0al.NIA\u2010AA Revised Clinical Guidelines for Alzheimer's n.d. (accessed July 17 2023).https:\/\/aaic.alz.org\/nia\u2010aa.asp"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001117\u20101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12395"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001071\u2010y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987\u2010022\u201000390\u20104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000013211"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12405"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911170"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12751"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010017\u20100314\u20102"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010018\u20100448\u2010x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.688478"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12674"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(1950)3:1<;32::aid\u2010cncr2820030106>3.0.co;2\u20103"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2019.1593949"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.17"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000010142"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001143\u2010z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001029\u20100"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102021\u2010327864"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.07.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002074\u2010w"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.5272"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.13909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:19:14Z","timestamp":1759943954000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/alz.13909"],"URL":"https:\/\/doi.org\/10.1002\/alz.13909","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,28]]},"assertion":[{"value":"2024-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}