{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:45:01Z","timestamp":1792003501557,"version":"4.4.0"},"reference-count":75,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008473","name":"Gebauer Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008473","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The combination of exergame\u2010based motor\u2010cognitive training with resonance breathing guided by heart\u2010rate variability biofeedback (HRV\u2010BF) targets various relevant mechanisms of action to alleviate the pathological state in mild neurocognitive disorders (mNCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This randomized controlled trial (RCT) investigated the effectiveness of adding this novel intervention approach to usual care in mNCD. The individualized intervention was delivered via the \u201cBrain\u2010IT\u201d training concept, which was iteratively co\u2010designed, tested, and refined with patient and public involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We observed statistically significant effects with large effect sizes for global cognitive performance, immediate verbal recall, and delayed verbal recall in favor of the intervention group. Fifty\u2010five percent of participants showed a clinically relevant improvement in response to training.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Confirmatory RCTs are warranted to investigate whether the observed improvements in cognitive performance translate to affecting the rates of progression to or onset of dementia and test the implementation of the training in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We proposed a novel intervention approach for mild neurocognitive disorders.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>It combines exergame\u2010based training with biofeedback\u2010guided resonance breathing.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our results confirm the effectiveness of this approach.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Fifty\u2010five percent of participants showed a clinically relevant improvement in response to training.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13913","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T13:48:11Z","timestamp":1716990491000},"page":"4747-4764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["\u201cBrain\u2010IT\u201d: Exergame training with biofeedback breathing in neurocognitive disorders"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-6524","authenticated-orcid":false,"given":"Patrick","family":"Manser","sequence":"first","affiliation":[{"name":"Motor Control and Learning Group, Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology ETH Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6542-7385","authenticated-orcid":false,"given":"Eling D.","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Motor Control and Learning Group, Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology ETH Zurich Zurich Switzerland"},{"name":"Department of Health OST \u2010 Eastern Swiss University of Applied Sciences  St. Gallen Switzerland"},{"name":"Division of Physiotherapy, Department of Neurobiology, Care Sciences, and Society Karolinska Institute Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization.Global status report on the public health response to dementia; 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