{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:57:39Z","timestamp":1787313459849,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) incorporated non\u2010hemorrhagic imaging markers. Their prevalence and significance in patients with cognitive impairment remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We studied 622 memory clinic patients with available magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers. Two raters assessed non\u2010hemorrhagic markers, and we explored their association with clinical characteristics through multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Most patients had mild cognitive impairment; median age was 71 years and 50% were female. Using the v2.0 criteria, possible or probable CAA increased from 75 to 383 patients. Sixty\u2010eight percent of the sample had non\u2010hemorrhagic CAA markers, which were independently associated with age (odds ratio [OR]\u00a0=\u00a01.04, 95% confidence interval [CI]\u00a0=\u00a01.01\u20131.07), female sex (OR\u00a0=\u00a01.68, 95% CI\u00a0=\u00a01.11\u20132.54), and hemorrhagic CAA markers (OR\u00a0=\u00a02.11, 95% CI\u00a0=\u00a01.02\u20134.35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Two\u2010thirds of patients from a memory clinic cohort had non\u2010hemorrhagic CAA markers, increasing the number of patients meeting the v2.0 CAA criteria. Longitudinal approaches should explore the implications of these markers, particularly the hemorrhagic risk in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The updated Boston criteria for cerebral amyloid angiopathy (CAA) now include non\u2010hemorrhagic markers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The prevalence of non\u2010hemorrhagic CAA markers in memory clinic patients is unknown.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Two\u2010thirds of patients in our memory clinic presented non\u2010hemorrhagic CAA markers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The presence of these markers was associated with age, female sex, and hemorrhagic CAA markers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The hemorrhagic risk of patients presenting these type of markers remains unclear.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13920","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:44:24Z","timestamp":1718199864000},"page":"4792-4802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Non\u2010hemorrhagic imaging markers of cerebral amyloid angiopathy in memory clinic patients"],"prefix":"10.1002","volume":"20","author":[{"given":"Ana Sofia","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"},{"name":"JARA Institute Molecular Neuroscience and Neuroimaging (INM\u201011) Juelich Research Center GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Nikoubashman","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"},{"name":"JARA Institute Molecular Neuroscience and Neuroimaging (INM\u201011) Juelich Research Center GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"},{"name":"JARA Institute Molecular Neuroscience and Neuroimaging (INM\u201011) Juelich Research Center GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Pinho","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen 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