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We measured AD\u2010related plasma biomarkers in a subsample (<jats:italic>n<\/jats:italic>\u00a0=\u00a01256). Data were analyzed using logistic and Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We developed PRS with (PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>) and without (PRS<jats:sub>non\u2010<\/jats:sub><jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>) apolipoprotein E <jats:italic>(APOE)<\/jats:italic> gene. In the longitudinal analysis, PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic> was associated with a multivariable\u2010adjusted hazards ratio of 1.91 (95% CI\u00a0=\u00a01.13\u20133.23) for AD. PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic> in combination with demographics yielded discriminative (area under the curve [AUC]) and predictive(C\u2010statistic) accuracy of 0.80 (95% confidence interval [CI]\u00a0=\u00a00.77\u20130.84) and 0.80 (0.77\u20130.82), respectively. PRS<jats:sub>non\u2010<\/jats:sub><jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic> showed an association with AD risk similar to PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>. PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>, but not PRS<jats:sub>non\u2010<\/jats:sub><jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>, was associated with reduced plasma A\u03b242\/A\u03b240 ratio and increased Neurofilament light chain (NfL) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The PRS with and without <jats:italic>APOE<\/jats:italic> gene, in combination with demographics, shows good discriminative and predictive ability for AD. The AD\u2010related pathologies underlie AD risk associated with PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic> and PRS<jats:sub>non\u2010<\/jats:sub><jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic> were associated with AD risk in the Chinese population.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic> and PRS<jats:sub>non\u2010<\/jats:sub><jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>, in combination with demographics, showed good discriminative and predictive ability for AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The AD\u2010related pathologies underlie the AD risk associated with PRS<jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic> but not PRS<jats:sub>non\u2010<\/jats:sub><jats:italic><jats:sub>APOE<\/jats:sub><\/jats:italic>.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13924","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:47:52Z","timestamp":1724341672000},"page":"6669-6681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community\u2010based study"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2614-8145","authenticated-orcid":false,"given":"Tingting","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong P.R. 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