{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:32:30Z","timestamp":1776508350376,"version":"3.51.2"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Primary age\u2010related tauopathy (PART), often regarded as a minimally symptomatic pathology of old age, lacks comprehensive cohorts across various age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We examined PART prevalence and clinicopathologic features in 1589 forensic autopsy cases (\u226540 years old, mean age\u00a0\u00b1\u00a0SD 70.2\u00a0\u00b1\u00a014.2 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>PART cases meeting criteria for argyrophilic grain diseases (AGD) were AGD+PART (<jats:italic>n<\/jats:italic>\u00a0=\u00a0181). The remaining PART cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a0719, 45.2%) were classified as comorbid conditions (PART\u2010C, <jats:italic>n<\/jats:italic>\u00a0=\u00a090) or no comorbid conditions (pure PART, <jats:italic>n<\/jats:italic>\u00a0=\u00a0629). Compared to controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a0208), Alzheimer's disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a0133), and AGD+PART, PART prevalence peaked in the individuals in their 60s (65.5%) and declined in the 80s (21.5%). No significant clinical background differences were found (excluding controls). However, PART\u2010C in patients inclusive of age 80 had a higher suicide rate than pure PART (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and AGD+PART showed more dementia (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and suicide (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) than pure PART.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our results advocate a reevaluation of the PART concept and its diagnostic criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We investigated 1589 forensic autopsy cases to investigate the features of primary age\u2010related tauopathy (PART).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>PART peaked in people in their 60s in our study.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Many PART cases over 80s had comorbid pathologies in addition to neurofibrillary tangles pathology.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Argyrophilic grain disease and Lewy pathology significantly affected dementia and suicide rates in PART.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our results suggest that the diagnostic criteria of PART need to be reconsidered.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14037","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T04:20:48Z","timestamp":1719548448000},"page":"5411-5420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and clinicopathological features of primary age\u2010related tauopathy (PART): A large forensic autopsy study"],"prefix":"10.1002","volume":"20","author":[{"given":"Koji","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Legal Medicine Faculty of Medicine University of Toyama  Toyama 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