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We expand current knowledge by examining A\u03b2 pathology, aging, cognition, and biomarker proteomics.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Amyloid immunoreactivity in the frontal cortex and temporal cortex\/hippocampal regions from archived vervet brain samples ranging from young adulthood to old age was quantified. We also obtained cognitive scores, plasma samples, and cerebrospinal fluid (CSF) samples in additional animals. Plasma and CSF proteins were quantified with platforms utilizing human antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We found age\u2010related increases in A\u03b2 deposition in both brain regions. Bioinformatic analyses assessed associations between biomarkers and age, sex, cognition, and CSF A\u03b2 levels, revealing changes in proteins related to immune\u2010related inflammation, metabolism, and cellular processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Vervets are an effective model of aging and early\u2010stage Alzheimer's disease, and we provide translational biomarker data that both align with previous results in humans and provide a basis for future investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We found changes in immune and metabolic plasma biomarkers associated with age and cognition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cerebrospinal fluid (CSF) biomarkers revealed changes in cell signaling indicative of adaptative processes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TNFRSF19 (TROY) and Artemin co\u2010localize with Alzheimer's disease pathology.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Vervets are a relevant model for translational studies of early\u2010stage Alzheimer's disease.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14038","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T05:15:27Z","timestamp":1719810927000},"page":"5460-5480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-7552","authenticated-orcid":false,"given":"Curran","family":"Varma","sequence":"first","affiliation":[{"name":"Department of Neurology Ann Romney Center for Neurologic Diseases Brigham and Women's Hospital  Boston Massachusetts 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