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Compared to those with pure AD, AD\u2010LBD patients showed worse global cognition, especially in attentive\/executive and visuospatial functions, and worse motor functions. In cognitively unimpaired individuals, concurrent AD\u2010LBD pathologies predicted longitudinal cognitive progression with faster worsening of global cognition, memory, and attentive\/executive functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Future research studies aiming for a better precision medicine approach should develop SAAs further to reach a quantitative evaluation or staging of each underlying pathology using a single biofluid sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>\u03b1\u2010Synuclein seed amplification assays (SAAs) provide a specific marker for Lewy body disease (LBD).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SAAs allow for the in vivo identification of co\u2010occurring LBD in patients with Alzheimer's disease (AD).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>AD\u2010LBD coexist in 20\u201025% of cognitively impaired elderly individuals, and \u223c8% of those asymptomatic.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Compared to pure AD, AD\u2010LBD causes a faster worsening of cognitive functions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>AD\u2010LBD is associated with worse attentive\/executive, memory, visuospatial and motor functions.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14039","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T21:45:01Z","timestamp":1719006301000},"page":"5757-5770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["In vivo detection of Alzheimer's and Lewy body disease concurrence: Clinical implications and future perspectives"],"prefix":"10.1002","volume":"20","author":[{"given":"Simone","family":"Baiardi","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Faculty of Medicine Lund University  Lund Sweden"},{"name":"Memory Clinic Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Munich Germany"},{"name":"Munich Cluster of Systems Neurology (SyNergy)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f39adc"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010019\u20100244\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100238\u20106"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010011\u20100910\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12311"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001382\u2010x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000403\u20103"},{"key":"e_1_2_11_9_1","unstructured":"Barth\u00e9lemyNR Salvad\u00f3G SchindlerSE et\u00a0al.A highly accurate blood test for Alzheimer's disease pathology has performance equivalent or superior to clinically used cerebrospinal fluid tests. 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