{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:18:28Z","timestamp":1788218308803,"version":"build-2803163510"},"reference-count":102,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG066203"],"award-info":[{"award-number":["R01AG066203"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>INTRODUCTION<\/jats:title>In this study, we investigated biomarkers in a midlife, racially diverse, at\u2010risk cohort to facilitate early identification and intervention. We examined neuroimaging measures, including resting state functional magnetic resonance imaging (fMRI), white matter hyperintensity vo (WMH), and hippocampal volumes, alongside cerebrospinal fluid (CSF) markers.<\/jats:p><\/jats:sec>METHODS<\/jats:title>Our data set included 76 cognitively unimpaired, middle\u2010aged, Black Americans (N<\/jats:italic>\u00a0=\u00a029, F\/M\u00a0=\u00a017\/12) and Non\u2010Hispanic White (N<\/jats:italic>\u00a0=\u00a047, F\/M\u00a0=\u00a027\/20) individuals. We compared cerebrospinal fluid phosphorylated tau141 and amyloid beta (A\u03b2)42 to fMRI default mode network (DMN) subnetwork connectivity, WMH volumes, and hippocampal volumes.<\/jats:p><\/jats:sec>RESULTS<\/jats:title>Results revealed a significant race \u00d7 A\u03b242 interaction in Black Americans: lower A\u03b242 was associated with reduced DMN connectivity and increased WMH volumes regions but not in non\u2010Hispanic White individuals.<\/jats:p><\/jats:sec>DISCUSSION<\/jats:title>Our findings suggest that precuneus DMN connectivity and temporal WMHs may be linked to Alzheimer's disease risk pathology during middle age, particularly in Black Americans.<\/jats:p><\/jats:sec>Highlights<\/jats:title>\nCerebrospinal fluid (CSF) amyloid beta (A\u03b2)42 relates to precuneus functional connectivity in Black, but not White, Americans.<\/jats:p><\/jats:list-item>\nHigher white matter hyperintensity volume relates to lower CSF A\u03b242 in Black Americans.<\/jats:p><\/jats:list-item>\nPrecuneus may be a hub for early Alzheimer's disease pathology changes detected by functional connectivity.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14051","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T07:02:08Z","timestamp":1723532528000},"page":"5961-5972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high\u2010risk cohort of middle\u2010aged adults"],"prefix":"10.1002","volume":"20","author":[{"given":"Maria","family":"Misiura","sequence":"first","affiliation":[{"name":"Department of Psychology Georgia State University Atlanta Georgia USA"},{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging & Data Science, Georgia State University, Georgia Institute of Technology Emory University Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinkuli","family":"Munkombwe","sequence":"additional","affiliation":[{"name":"Neuroscience Institute Georgia State University Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Igwe","sequence":"additional","affiliation":[{"name":"Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. 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