{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:22:18Z","timestamp":1784035338998,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Despite prior research on the association between sarcopenia and cognitive impairment in the elderly, a comprehensive model that integrates various brain pathologies is still lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We used data from 528 non\u2010demented older adults with or without sarcopenia in the Catholic Aging Brain Imaging (CABI) database, containing magnetic resonance imaging scans, positron emission tomography scans, and clinical data. We also measured three key components of sarcopenia: skeletal muscle index (SMI), hand grip strength (HGS), and the five times sit\u2010to\u2010stand test (5STS).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All components of sarcopenia were significantly correlated with global cognitive function, but cortical thickness and amyloid\u2010beta (A\u03b2) retention had distinctive relationships with each measure. In the path model, brain atrophy resulting in cognitive impairment was mediated by A\u03b2 retention for SMI and periventricular white matter hyperintensity for HGS, but directly affected by the 5STS.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Treatments targeting each sub\u2010domain of sarcopenia should be considered to prevent cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We identified distinct impacts of three sarcopenia measures on brain structure and A\u03b2.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Muscle mass is mainly associated with A\u03b2 and has an influence on the brain atrophy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Muscle strength linked with periventricular WMH and brain atrophy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Muscle function associated with cortical thinning in specific brain regions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Interventions on sarcopenia may be important to ease cognitive decline in the elderly.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14054","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T14:01:26Z","timestamp":1718719286000},"page":"4868-4878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Development of a prediction model for cognitive impairment of sarcopenia using multimodal neuroimaging in non\u2010demented older adults"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-4369","authenticated-orcid":false,"given":"Sunghwan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Hyun","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Psychiatry St. Vincent's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Min","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Sim","family":"Choe","sequence":"additional","affiliation":[{"name":"Research Institute Neurophet Inc.  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