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Since socializing behaviors may cluster together or act compensatorily, we aimed to investigate social connection patterns and their association with dementia, for men and women separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 12,896 community\u2010dwelling older adults (mean\u00a0\u00b1\u00a0SD age: 75.2\u00a0\u00b1\u00a04.3 years, 54% women) without major cognitive impairment were included. Latent class analysis was conducted using 24 baseline social connection indicators. Cox proportional hazards regression was used to estimate the association between latent classes and incident dementia over 12 (median: 8.4) years follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Three distinct classes were identified in both genders: strong social connections with an intermediate friend\u2010relative network (Class 1: men, 43.8%; women, 37.9%), weak social connections (Class 2: men, 29.6%; women, 27.4%), and strong social connections with a larger friend\u2010relative network (Class 3: men, 26.6%; women, 34.7%). Compared to Class 1, men in Class 2 (HR: 1.38, 95% CI: 1.08\u20101.77) and women in Class 3 (HR: 1.27, 95% CI: 1.01\u20101.60) had an increased risk of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Dementia risk varies with different social connection patterns among older men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Three distinct social connection patterns were identified based on 24 indicators.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These patterns were related to dementia risk differently in men and women.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In men, a weak social connection pattern was associated with a higher dementia risk.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In women, a strong social connection with a relatively larger friend\u2010relative network was associated with a greater dementia risk.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14055","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:23:23Z","timestamp":1718353403000},"page":"4879-4890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gender\u2010specific analysis of social connection patterns and risk of dementia in community\u2010dwelling older people"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-0610","authenticated-orcid":false,"given":"Htet Lin","family":"Htun","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9993","authenticated-orcid":false,"given":"Achamyeleh 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