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We checked the sensitivity of time\u2010encoded arterial spin labeling (te\u2010ASL) in measuring CBF alterations in individuals with positive AD biomarkers and associations with relevant biomarkers in cognitively unimpaired (CU) individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We compared te\u2010ASL with single\u2010postlabel delay (PLD) ASL in measuring CBF in 59 adults across the AD continuum, classified as CU amyloid beta (A\u03b2) negative (\u2212), CU A\u03b2 positive (+), and CI A\u03b2+. We sought associations of CBF with biomarkers of AD, cerebrovascular disease, synaptic dysfunction, neurodegeneration, and cognition in CU participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>te\u2010ASL was more sensitive at detecting CBF reduction in the CU A\u03b2+ and CI A\u03b2+ groups. In CU participants, lower CBF was associated with altered biomarkers of A\u03b2, tau, synaptic dysfunction, and neurodegeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>CBF reduction occurs early in the AD continuum. te\u2010ASL is more sensitive than single\u2010PLD ASL at detecting CBF changes in AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Lower CBF can be detected in CU subjects in the early AD continuum.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>te\u2010ASL is more sensitive than single\u2010PLD ASL at detecting CBF alterations in AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CBF is linked to biomarkers of AD, synaptic dysfunction, and neurodegeneration.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14059","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T09:44:20Z","timestamp":1719999860000},"page":"5183-5197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Time\u2010encoded ASL reveals lower cerebral blood flow in the early AD continuum"],"prefix":"10.1002","volume":"20","author":[{"given":"Carles","family":"Falcon","sequence":"first","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER\u2010BBN) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Neuroimagen de Enfermedades Neurodegenerativas y Envejecimiento Saludable Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Philips Healthcare Iberia Mar\u00eda de Portugal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"V\u00e1clav\u016f","sequence":"additional","affiliation":[{"name":"Department of Radiology, C. 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