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This score significantly predicted the prospective development of cognitive impairments in independent studies of Alzheimer's disease (hazard ratio for Rey's Auditory Verbal Learning Test (RAVLT)\u2010Learning\u00a0=\u00a02.47) and Parkinson's disease (hazard ratio for MCI\/dementia<jats:sub>\u00a0<\/jats:sub>=\u00a02.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our work shows the potential of employing blood\u2010derived DNA methylation data in the assessment of dementia risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We used whole blood DNA methylation as a surrogate for 14 dementia risk factors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Created a multivariate methylation risk score for predicting cognitive impairment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Emphasized the role of machine learning and omics data in predicting dementia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The score predicts cognitive impairment development at the population level.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14061","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T07:00:35Z","timestamp":1724828435000},"page":"6682-6698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Blood\u2010based multivariate methylation risk score for cognitive impairment and dementia"],"prefix":"10.1002","volume":"20","author":[{"given":"Jarno","family":"Koetsier","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University  Maastricht The Netherlands"},{"name":"Department of Biochemistry Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Cavill","sequence":"additional","affiliation":[{"name":"Department of Advanced Computing Sciences (DACS) Faculty of Science and Engineering (FSE) Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Reijnders","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Harvey","sequence":"additional","affiliation":[{"name":"Medical School Faculty of Health and Life Sciences University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Homann","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Social Medicine University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Kouhsar","sequence":"additional","affiliation":[{"name":"Medical School Faculty of Health and Life Sciences University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Deckers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars M. 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