{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:50:20Z","timestamp":1794282620740,"version":"4.9.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Evidence for the effect of early menopause on cognition among older women is not consistent and is scant among the Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We aimed to examine the effect of early menopause (\u226445 years) on cognitive performance and brain morphology among older dementia\u2010free females of the TLSA cohort using a multiple linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In a sample of 528 women, 144 (27%) had early menopause. The linear regression analysis showed that women with early menopause performed poorly in cognition and had lesser total gray matter volume [\u03b2\u00a0=\u00a0\u221211973.94, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033], left middle frontal [\u03b2\u00a0=\u00a0\u2212353.14, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033], and left superior frontal [\u03b2\u00a0=\u00a0\u2212460.97, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.026] volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Dementia\u2010free women with early menopause had poorer cognition, lower total gray matter, and frontal lobe. More research is needed to explore the link between earlier menopause and cognitive decline and develop ways to address it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Evidence on the effect of early menopause on brain morphology is inconsistent and scant in low and middle\u2010income countries, such as India.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In a cohort of dementia\u2010free individuals in urban Bangalore, we observed that participants with early menopause had significantly lower cognitive performance and lower total gray matter and frontal lobe volume.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We recommend increasing awareness of this fact among the medical community and the general public. There is an urgent need to explore the underlying biological mechanism and to discover effective interventions to mitigate the effect.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14069","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T05:19:12Z","timestamp":1719811152000},"page":"5607-5616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of early menopause on cognition and brain morphology in an Urban Indian Cohort"],"prefix":"10.1002","volume":"20","author":[{"given":"Abhishek","family":"Mensegere","sequence":"first","affiliation":[{"name":"Centre for Brain Research IISc  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhana","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre for Brain Research IISc  Bangalore Karnataka 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