{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:07:41Z","timestamp":1791360461323,"version":"4.3.1"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>This study investigated the potential of phosphorylated plasma Tau217 ratio (pTau217R) and plasma amyloid beta (A\u03b2) 42\/A\u03b240 in predicting brain amyloid levels measured by positron emission tomography (PET) Centiloid (CL) for Alzheimer's disease (AD) staging and screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Quantification of plasma pTau217R and A\u03b242\/A\u03b240 employed immunoprecipitation\u2010mass spectrometry. CL prediction models were developed on a cohort of 904 cognitively unimpaired, preclinical\u00a0and early AD subjects and validated on two independent cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Models integrating pTau217R outperformed A\u03b242\/A\u03b240 alone, predicting amyloid levels up to 89.1 CL. High area under the receiver operating characteristic curve (AUROC) values (89.3% to 94.7%) were observed across a broad CL range (15 to 90). Utilizing pTau217R\u2010based models for low amyloid levels reduced PET scans by 70.5% to 78.6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>pTau217R effectively predicts brain amyloid levels, surpassing cerebrospinal fluid A\u03b242\/A\u03b240's range. Combining it with plasma A\u03b242\/A\u03b240 enhances sensitivity for low amyloid detection, reducing unnecessary PET scans and expanding clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICALTRIALS.GOV IDENTIFIERS<\/jats:title>\n                    <jats:p>NCT02956486 (MissionAD1), NCT03036280 (MissionAD2), NCT04468659 (AHEAD3\u201045), NCT03887455 (ClarityAD)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Phosphorylated plasma Tau217 ratio (pTau217R) effectively predicts amyloid\u2010PET Centiloid (CL) across a broad spectrum.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Integrating pTau217R with A\u03b242\/A\u03b240 extends the CL prediction upper limit to 89.1 CL.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Combined model predicts amyloid status with high accuracy, especially in cognitively unimpaired individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This model\u00a0identifies subjects above or below various CL thresholds with high accuracy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>pTau217R\u2010based models significantly reduce PET scans by up to 78.6% for screening out individuals with no\/low amyloid.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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