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According to the standardized uptake value ratio (SUVR) and A\u03b2 stage classification, correlation analysis was performed among plasma biomarkers, and voxel\/SUVR values in the regions of interest (ROI) and clinical scale information, respectively. Mediation analysis was used to study the possible pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The proportion of cognitively normal (CN) and subjective cognitive decline (SCD) was the highest in stages A0 to 1, while in stages A2 to 4, the proportion of mild cognitive impairment (MCI) and AD increased. Plasma phosphorylated tau (p\u2010tau)181 and glial fibrillary acidic protein (GFAP) levels were significantly lower in stage A0 compared to the later phases. Two pathways demonstrated fully mediated effects: positron emission tomography (PET) SUVR\u2013plasma p\u2010tau181\u2013Mini\u2010Mental State Examination (MMSE) and PET SUVR\u2013plasma GFAP\u2013MMSE.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>This study demonstrated the role of plasma biomarkers in the early stage of AD, especially in SCD, from both the clinical diagnosis and A\u03b2 stage dimensions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Plasma ptau181 and GFAP level serve as indicators of early Alzheimer's disease and the pathologic A\u03b2 staging classification.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A possible ceiling effect of GFAP was observed in the mid\u2010to\u2010late stages of the AD course.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This study confirms the role of AD plasma markers in promoting A\u03b2 deposition at an early stage, particularly in females with subjective cognitive decline(SCD).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The overlapping brain regions of plasma p\u2010tau181, GFAP, and neurofilament light for A\u03b2 deposition in the brain in early AD were distributed across various regions, including the posterior cingulate gyrus, rectus gyrus, and inferior temporal gyrus.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14084","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T03:19:47Z","timestamp":1720581587000},"page":"6170-6182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Correlations between plasma markers and brain A\u03b2 deposition across the AD continuum: Evidence from SILCODE"],"prefix":"10.1002","volume":"20","author":[{"given":"Xianfeng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of 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