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characteristics (ROC) analyses to determine diagnostic accuracy. We validated our findings in two independent cohorts and constructed a visualization approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>P\u2010tau181, GFAP, and NfL were selected. This combination had area under the curve (AUC)\u00a0=\u00a083% to identify amyloid positivity in pre\u2010dementia stages, AUC\u00a0=\u00a087%\u201389% to differentiate Alzheimer's or controls from frontotemporal dementia, AUC\u00a0=\u00a074%\u201376% to differentiate Alzheimer's or controls from dementia with Lewy bodies. Highly reproducible AUCs were obtained in independent cohorts. The resulting visualization tool includes UpSet plots to visualize the stand\u2010alone biomarker results and density plots to visualize the biomarker results combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our multimarker blood test interpretation tool is ready for testing in real\u2010world clinical dementia settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We developed a multimarker blood test interpretation tool for clinical dementia practice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our interpretation tool includes plasma biomarkers P\u2010tau, GFAP, and NfL.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our tool is particularly useful for Alzheimer's and frontotemporal dementia diagnosis.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14088","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T06:59:49Z","timestamp":1722668389000},"page":"6115-6132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Development of thresholds and a visualization tool for use of a blood test in routine clinical dementia practice"],"prefix":"10.1002","volume":"20","author":[{"given":"Inge M. 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