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Yet most known loci have only identified from the late\u2010onset type AD in populations of European ancestry.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We performed a two\u2010stage genome\u2010wide association study (GWAS) of AD totaling 6878 Chinese and 63,926 European individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In addition to the apolipoprotein E (<jats:italic>APOE<\/jats:italic>) locus, our GWAS of two independent Chinese samples uncovered three novel AD susceptibility loci (<jats:italic>KIAA2013<\/jats:italic>, <jats:italic>SLC52A3<\/jats:italic>, and <jats:italic>TCN2<\/jats:italic>) and a novel ancestry\u2010specific variant within <jats:italic>EGFR<\/jats:italic> (rs1815157). More replicated variants were observed in the Chinese (31%) than in the European samples (15%). In combining genome\u2010wide associations and functional annotations, <jats:italic>EGFR<\/jats:italic> and <jats:italic>TCN2<\/jats:italic> were prioritized as two of the most biologically significant genes. Phenome\u2010wide Mendelian randomization suggests that high mean corpuscular hemoglobin concentration might protect against AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The current study reveals novel AD susceptibility loci, emphasizes the importance of diverse populations in AD genetic research, and advances our understanding of disease etiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Loci <jats:italic>KIAA2013<\/jats:italic>, <jats:italic>SLC52A3<\/jats:italic>, and <jats:italic>TCN2<\/jats:italic> were associated with Alzheimer's disease (AD) in Chinese populations.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>rs1815157 within the <jats:italic>EGFR<\/jats:italic> locus was associated with AD in Chinese populations.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The genetic architecture of AD varied between Chinese and European populations.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:italic>EGFR<\/jats:italic> and <jats:italic>TCN2<\/jats:italic> were prioritized as two of the most biologically significant genes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>High mean corpuscular hemoglobin concentrations might have protective effects against AD.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14121","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T06:28:28Z","timestamp":1721284108000},"page":"6243-6256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genome\u2010wide meta\u2010analysis identifies ancestry\u2010specific loci for Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Yi\u2010Jun","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital 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