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Moderation models explored the moderating effect of IPS on associations between EM and imaging features at single\u2010region, connectivity, and network levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>IPS significantly enhanced the positive correlations between recall and cortical thickness of left inferior temporal gyrus. IPS also notably amplified negative correlations between recognition and functional connectivity (FC) of left inferior parietal lobe and right occipital, as well as between recall\/recognition and nodal clustering coefficient of left anterior cingulate cortex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>IPS functioned as a moderator of associations between recall and neuroimaging metrics at the \u201csingle region\u2010connectivity\u2010network\u201d level, providing new insights for cognitive rehabilitation in aMCI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>aMCI patients exhibited brain functional and structural remodeling alterations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>IPS moderated relations between episodic memory and brain remodeling metrics.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Therapy targeted at IPS can be considered for improving episodic memory in aMCI.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14130","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T04:39:46Z","timestamp":1724819986000},"page":"6793-6809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The moderating role of information processing speed in the relationship between brain remodeling and episodic memory in amnestic mild cognitive impairment"],"prefix":"10.1002","volume":"20","author":[{"given":"Jie","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan\u2010Juan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Yueyang Hospital of Integrated 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