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Both plasma and CSF genome\u2010wide association study (GWAS) analyses were performed for each protein, followed by functional annotation. Additional characterization for each biomarker included calculation of correlations and predictive power.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Eighteen plasma protein quantitative train loci (pQTLs) associated with 10 proteins and 16 CSF pQTLs associated with 9 proteins were identified. Plasma and CSF shared some genetic loci, but protein levels between tissues correlated weakly. CSF protein levels better associated with AD compared to plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The present results indicate that CSF is more informative than plasma for genetic studies in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The identification of novel protein quantitative trait loci (pQTLs) in both plasma and cerebrospinal fluid (CSF).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma and CSF levels of neurodegeneration\u2010related proteins correlated weakly.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSF is more informative than plasma for genetic studies of Alzheimer's disease (AD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Neurofilament light (NfL), triggering receptor expressed on myeloid cells 2 (TREM2), and chitinase\u20103\u2010like protein 1 (YKL\u201040) tend to show relatively strong inter\u2010tissue associations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            A novel signal in the apolipoprotein E (\n                            <jats:italic>APOE<\/jats:italic>\n                            ) region was identified, which is an eQTL for\n                            <jats:italic>APOC1<\/jats:italic>\n                            .\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14139","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T05:55:34Z","timestamp":1722318934000},"page":"6423-6440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A genetic and proteomic comparison of key AD biomarkers across tissues"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8565-3788","authenticated-orcid":false,"given":"Thomas W.","family":"Marsh","sequence":"first","affiliation":[{"name":"Division of Biology &amp; Biomedical Sciences Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Psychiatry Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Neurogenomics and Informatics Washington University in St. Louis  St. Louis Missouri 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