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Here, we assessed what utility or added value these digital cognitive assessments provide for identifying those at high risk of cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed\u00a0&gt;500 Alzheimer's Disease Neuroimaging Initiative participants who underwent a brief digital cognitive assessment and amyloid beta (A\u03b2)\/tau positron emission tomography scans, examining their ability to distinguish cognitive status and predict cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Performance on the digital cognitive assessment was superior to both cortical A\u03b2 and entorhinal tau in detecting mild cognitive impairment and future cognitive decline, with mnemonic discrimination deficits emerging as the most critical measure for predicting decline and future tau accumulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Digital assessments are effective at identifying at\u2010risk individuals, supporting their utility as low\u2010burden tools for early AD detection and monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Performance on digital cognitive assessments predicts progression to mild cognitive impairment at a higher proficiency compared to amyloid beta and tau.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Deficits in mnemonic discrimination are indicative of future cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Impaired mnemonic discrimination predicts future entorhinal and inferior temporal tau.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14154","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:30:00Z","timestamp":1725611400000},"page":"6881-6895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Digital cognitive assessments as low\u2010burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum"],"prefix":"10.1002","volume":"20","author":[{"given":"Casey R.","family":"Vanderlip","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Behavior 1424 Biological Sciences III Irvine, University of California Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E. 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