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Using mean temporo\u2010frontoparietal FC as a classifier could improve accuracy in identifying ilMCI subgroups with positive cerebral amyloid deposition and\n                      <jats:italic>APOE<\/jats:italic>\n                      risk alleles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Temporal\u2010frontoparietal hypoconnectivity was observed in individuals with ilMCI, which may reflect semantic impairment and serve as a valuable biomarker to indicate potential mechanisms of underlying neuropathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Temporo\u2010frontoparietal hypoconnectivity was observed in impaired language mild cognitive impairment (ilMCI).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Temporo\u2010frontoparietal hypoconnectivity may reflect semantic impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Temporo\u2010frontoparietal functional connectivity can classify ilMCI subtypes.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14155","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:55:39Z","timestamp":1723118139000},"page":"6566-6578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Temporo\u2010frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross\u2010cohort comparison"],"prefix":"10.1002","volume":"20","author":[{"given":"Lin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gerontology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering School of Life Sciences Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gerontology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department 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