{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:38:26Z","timestamp":1782520706348,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Cerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific cognitive profiles, cognitive function in the stage before intracerebral hemorrhage (ICH), and the association between magnetic resonance imaging (MRI) based cerebral small vessel disease (cSVD) burden in CAA because data on these topics are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We included Dutch\u2010type hereditary CAA (D\u2010CAA) mutation carriers with and without ICH, patients with sporadic CAA (sCAA), and age\u2010matched controls. Cognition was measured with a standardized test battery. Linear regression was performed to assess the association between MRI\u2010cSVD burden and cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>D\u2010CAA ICH\u2212 mutation carriers exhibited poorer global cognition and executive function compared to age\u2010matched controls. Patients with sCAA performed worse across all cognitive domains compared to D\u2010CAA ICH+ mutation carriers and age\u2010matched controls. MRI\u2010cSVD burden is associated with decreased processing speed.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>CAA is associated with dysfunction in multiple cognitive domains, even before ICH, with increased MRI\u2010cSVD burden being associated with slower processing speed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cognitive dysfunction is present in early disease stages of cerebral amyloid angiopathy (CAA) before the occurrence of symptomatic intracerebral hemorrhage (sICH).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Presymptomatic Dutch\u2010type CAA (D\u2010CAA) mutation carriers show worse cognition than age\u2010matched controls.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>More early awareness of cognitive dysfunction in CAA before first sICH is needed.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Increased cerebral small vessel disease CAA\u2010burden on magnetic resonance imaging is linked to a decrease in processing speed.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14171","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:04:49Z","timestamp":1728554689000},"page":"7518-7528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cognition in (pre)symptomatic Dutch\u2010type hereditary and sporadic cerebral amyloid angiopathy"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-3189","authenticated-orcid":false,"given":"Rosemarie","family":"van Dort","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanishk","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Rasing","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier G. 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