{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:50:01Z","timestamp":1793400601068,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG10161"],"award-info":[{"award-number":["P30AG10161"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG15819"],"award-info":[{"award-number":["R01AG15819"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG17917"],"award-info":[{"award-number":["R01AG17917"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG30146"],"award-info":[{"award-number":["R01AG30146"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG36042"],"award-info":[{"award-number":["R01AG36042"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RC2AG036547"],"award-info":[{"award-number":["RC2AG036547"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG36836"],"award-info":[{"award-number":["R01AG36836"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG48015"],"award-info":[{"award-number":["R01AG48015"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG57473"],"award-info":[{"award-number":["RF1AG57473"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG32984"],"award-info":[{"award-number":["U01AG32984"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG46152"],"award-info":[{"award-number":["U01AG46152"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG46161"],"award-info":[{"award-number":["U01AG46161"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG61356"],"award-info":[{"award-number":["U01AG61356"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01\u2010AG048927"],"award-info":[{"award-number":["R01\u2010AG048927"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG058654"],"award-info":[{"award-number":["U01\u2010AG058654"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U54\u2010AG052427"],"award-info":[{"award-number":["U54\u2010AG052427"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19\u2010AG068753"],"award-info":[{"award-number":["U19\u2010AG068753"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG062602"],"award-info":[{"award-number":["U01\u2010AG062602"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG072577"],"award-info":[{"award-number":["U01\u2010AG072577"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01\u2010AG080810"],"award-info":[{"award-number":["R01\u2010AG080810"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004888","name":"Illinois Department of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017803","name":"Translational Genomics Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n The molecular basis of cognitive resilience (CR) among pathologically confirmed Alzheimer's disease (AD) cases is not well understood.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Abundance of 13 cell types and neuronal subtypes in brain bulk RNA\u2010seq data from the anterior caudate, dorsolateral prefrontal cortex (DLPFC), and posterior cingulate cortex (PCC) obtained from 434 AD cases, 318 cognitively resilient AD cases, and 188 controls in the Religious Orders Study and Rush Memory and Aging Project was estimated by deconvolution.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n PVALB+ neuron abundance was negatively associated with cognitive status and tau pathology in the DLPFC and PCC (\n P<\/jats:italic>\n adj\u00a0<\/jats:sub>\n <\u00a00.001) and the most reduced neuronal subtype in AD cases compared to controls in DLPFC (\n P<\/jats:italic>\n adj\u00a0<\/jats:sub>\n =\u00a08.4\u00a0\u00d7\u00a010\n \u22127<\/jats:sup>\n ) and PCC (\n P<\/jats:italic>\n adj\u00a0<\/jats:sub>\n =\u00a00.0015). We identified genome\u2010wide significant association of neuron abundance with\n TMEM106B<\/jats:italic>\n single nucleotide polymorphism rs13237518 in PCC (\n p\u00a0<\/jats:italic>\n =\u00a06.08\u00a0\u00d7\u00a010\n \u221212<\/jats:sup>\n ). rs13237518 was also associated with amyloid beta (\n p\u00a0<\/jats:italic>\n =\u00a00.0085) and tangles (\n p\u00a0<\/jats:italic>\n =\u00a00.0073).\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n \n High abundance of PVALB+ neurons may be a marker of CR.\n TMEM106B<\/jats:italic>\n variants may influence CR independent of AD pathology.\n <\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Neuron retention and a lack of astrocytosis are highly predictive of Alzheimer's disease (AD) resilience.<\/jats:p>\n <\/jats:list-item>\n \n \n PVALB+ GABAergic and\n RORB<\/jats:italic>\n + glutamatergic neurons are associated with cognitive status.\n <\/jats:p>\n <\/jats:list-item>\n \n \n A\n TMEM106B<\/jats:italic>\n single nucleotide polymorphism is related to lower AD risk, higher neuron count, and increased AD pathology.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14187","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T06:37:37Z","timestamp":1726123057000},"page":"6910-6921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cognitive resilience to Alzheimer's disease characterized by cell\u2010type abundance"],"prefix":"10.1002","volume":"20","author":[{"given":"Nicholas","family":"O'Neill","sequence":"first","affiliation":[{"name":"Bioinformatics Program Boston University Boston Massachusetts USA"},{"name":"Department of Medicine (Section of Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor D.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"VA Bedford Healthcare System Bedford Massachusetts USA"},{"name":"VA Boston Healthcare Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin A.","family":"Olayinka","sequence":"additional","affiliation":[{"name":"Bioinformatics Program Boston University Boston Massachusetts USA"},{"name":"Department of Medicine (Section of Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny A.","family":"Empawi","sequence":"additional","affiliation":[{"name":"Department of Medicine (Section of Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Hu","sequence":"additional","affiliation":[{"name":"Bioinformatics Program Boston University Boston Massachusetts USA"},{"name":"Department of Medicine (Section of Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Tong","sequence":"additional","affiliation":[{"name":"Bioinformatics Program Boston University Boston Massachusetts USA"},{"name":"Department of Medicine (Section of Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bioinformatics Program Boston University Boston Massachusetts USA"},{"name":"Department of Medicine (Section of Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Farrer","sequence":"additional","affiliation":[{"name":"Bioinformatics Program Boston University Boston Massachusetts USA"},{"name":"Department of Medicine (Section of Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA"},{"name":"Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Department of Ophthalmology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.06.014"},{"issue":"2","key":"e_1_2_9_4_1","first-page":"152","article-title":"Hippocampal neuronal loss in the CA1 and CA3 areas of Alzheimer's disease patients","volume":"24","author":"Padurariu M","year":"2012","journal-title":"Psychiatr Danub"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002369"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0815-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt171"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0479-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180942"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008120"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1195-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2008762117"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0539-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.039"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1710"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0114-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08023-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-018-0551-4"},{"key":"e_1_2_9_20_1","first-page":"5","article-title":"Multi\u2010cellular communities are perturbed in the aging human brain and with Alzheimer's disease","volume":"4","author":"Cain A","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8464"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"1","article-title":"Cellular deconvolution of GTEx tissues powers discovery of disease and cell\u2010type associated regulatory variants","volume":"11","author":"Donovan MKR","year":"2020","journal-title":"Nat Commun"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02066-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05476-w"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1506-7"},{"issue":"1","key":"e_1_2_9_27_1","first-page":"1","article-title":"Integrative cross\u2010species analysis of GABAergic neuron cell types and their functions in Alzheimer's disease","volume":"12","author":"Wang S","year":"2022","journal-title":"Sci Rep"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01329-z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00495-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01685-y"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.536"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0531-3"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2019.103397"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.903175"},{"key":"e_1_2_9_36_1","article-title":"Single\u2010cell deconvolution of 3,000 post\u2010mortem brain samples for eQTL and GWAS dissection in mental disorders","author":"Park Y","year":"2021","journal-title":"bioRxiv"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.037"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.040"},{"key":"e_1_2_9_39_1","article-title":"Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer's disease","author":"Green GS","year":"2023","journal-title":"bioRxiv"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.038"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.005"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00764-7"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02168-y"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101271"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz016"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.02.024"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181190"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091419855541"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3269-07.2007"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12800"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04650-z"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02702-4"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr007"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds475"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2014.07.006"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02246-3"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002287"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108189"}],"container-title":["Alzheimer's & Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:41:51Z","timestamp":1759934511000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/alz.14187"],"URL":"https:\/\/doi.org\/10.1002\/alz.14187","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"2024-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}