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Clinicians must ensure they are using accurate and well\u2010validated biomarker tests and select the most appropriate testing modality for each patient based on individual and practical considerations. The interpretation of test results may be complex and depends on the pre\u2010test probability and test\u2010specific factors. Biomarker results must be presented and discussed with patients in a process that is sensitive to the major implications of the results and is carefully connected to diagnosis, prognosis, and management. Advances in treatments for Alzheimer's disease will likely require non\u2010dementia specialists to use biomarkers, necessitating major educational efforts. 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