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LATE\u2010NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE\u2010NC is associated with a more rapid course. With the emergence of anti\u2010amyloid therapeutics, discrimination of LATE\u2010NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co\u2010pathology with LATE\u2010NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE\u2010NC. We propose criteria for clinical diagnosis of LATE as an initial framework for further validation. In the context of progressive memory loss and substantial hippocampal atrophy, criteria are laid out for probable (amyloid negative) or possible LATE (amyloid biomarkers are unavailable or when amyloid is present, but hippocampal neurodegeneration is out of proportion to expected pure ADNC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy (LATE) is a highly prevalent driver of neuropathologic memory loss in late life.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LATE neuropathologic change (LATE\u2010NC) is a common co\u2010pathology with Alzheimer's disease neuropathologic change (ADNC) and may influence outcomes with emerging disease\u2010modifying medicines.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We provide initial clinical criteria for diagnosing LATE during life either when LATE\u2010NC is the likely primary driver of symptoms or when observed in conjunction with AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Definitions of possible and probable LATE are provided.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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