{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:41:05Z","timestamp":1782531665412,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG024904"],"award-info":[{"award-number":["U19AG024904"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG024904"],"award-info":[{"award-number":["U19 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Speech\u2010based testing shows promise for sensitive and scalable objective screening for Alzheimer's disease (AD), but research to date offers limited evidence of generalizability.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data were taken from the AMYPRED (Amyloid Prediction in Early Stage Alzheimer's Disease from Acoustic and Linguistic Patterns of Speech) studies (<jats:italic>N<\/jats:italic>\u00a0=\u00a0101, <jats:italic>N<\/jats:italic>\u00a0=\u00a046 mild cognitive impairment [MCI]) and Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) remote digital (<jats:italic>N<\/jats:italic>\u00a0=\u00a0426, <jats:italic>N<\/jats:italic>\u00a0=\u00a058 self\u2010reported MCI, mild AD or dementia) and in\u2010clinic (<jats:italic>N<\/jats:italic>\u00a0=\u00a057, <jats:italic>N<\/jats:italic>\u00a0=\u00a013 MCI) cohorts, in which participants provided audio\u2010recorded responses to automated remote story recall tasks in the Storyteller test battery. Text similarity, lexical, temporal, and acoustic speech feature sets were extracted. Models predicting early AD were developed in AMYPRED and tested out of sample in the demographically more diverse cohorts in ADNI4 (&gt;\u00a033% from historically underrepresented populations).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Speech models generalized well to unseen data in ADNI4 remote and in\u2010clinic cohorts. The best\u2010performing models evaluated text\u2010based metrics (text similarity, lexical features: area under the curve 0.71\u20130.84 across cohorts).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Speech\u2010based predictions of early AD from Storyteller generalize across diverse samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The Storyteller speech\u2010based test is an objective digital prescreener for Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Speech\u2010based models predictive of Alzheimer's disease (AD) were developed in the AMYPRED (Amyloid Prediction in Early Stage Alzheimer's Disease from Acoustic and Linguistic Patterns of Speech) sample (<jats:italic>N<\/jats:italic>\u00a0=\u00a0101).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Models were tested out of sample in ADNI4 in\u2010clinic (<jats:italic>N<\/jats:italic>\u00a0=\u00a057) and remote (<jats:italic>N<\/jats:italic>\u00a0=\u00a0426) cohorts.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Models showed good generalization out of sample.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Models evaluating text matching and lexical features were most predictive of early AD.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14206","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T05:36:44Z","timestamp":1725514604000},"page":"7248-7262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Storyteller in ADNI4: Application of an early Alzheimer's disease screening tool using brief, remote, and speech\u2010based testing"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-7787","authenticated-orcid":false,"given":"Caroline","family":"Skirrow","sequence":"first","affiliation":[{"name":"Novoic Ltd London England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udeepa","family":"Meepegama","sequence":"additional","affiliation":[{"name":"Novoic Ltd London England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Weston","sequence":"additional","affiliation":[{"name":"Novoic Ltd London England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education (NCIRE) San Francisco California USA"},{"name":"VA Advanced Imaging Research Center Department of Veterans Affairs Medical Center San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Nosheny","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education (NCIRE) San Francisco California USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of California San Francisco  San Francisco California USA"},{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Albala","sequence":"additional","affiliation":[{"name":"Department of Environmental &amp; Occupational Health Public Health, University of California Irvine  Irvine California USA"},{"name":"Department of Neurology University of California Irvine School of Medicine  Irvine California USA"},{"name":"Department of Pharmaceutical Sciences University of California Irvine School of Pharmacy &amp; Pharmaceutical Sciences  Irvine California USA"},{"name":"Research Service, Veterans Administration Long Beach Healthcare System  Long Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education (NCIRE) San Francisco California USA"},{"name":"VA Advanced Imaging Research Center Department of Veterans Affairs Medical Center San Francisco California USA"},{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Fristed","sequence":"additional","affiliation":[{"name":"Novoic Ltd London England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.36"},{"key":"e_1_2_9_3_1","unstructured":"HeW GoodkindD KowalP.An aging world: 2015. international population reports.United States Census Bureau;2016. 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