{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:44:17Z","timestamp":1784234657840,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["2R25MH101076\u201006A1"],"award-info":[{"award-number":["2R25MH101076\u201006A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2P01AG051449\u201006"],"award-info":[{"award-number":["2P01AG051449\u201006"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG068990"],"award-info":[{"award-number":["R01AG068990"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201012\u20102\u20100012"],"award-info":[{"award-number":["W81XWH\u201012\u20102\u20100012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007742","name":"BioClinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014400","name":"Fujirebio US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>The relationship between cerebrovascular disease (CVD) and amyloid beta (A\u03b2) in Alzheimer's disease (AD) is understudied. We hypothesized that magnetic resonance imaging (MRI)\u2013based CVD biomarkers\u2014including cerebral microbleeds (CMBs), lacunar infarction, and white matter hyperintensities (WMHs)\u2014would correlate with A\u03b2 positivity on positron emission tomography (A\u03b2\u2010PET).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We cross\u2010sectionally analyzed data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, <jats:italic>N<\/jats:italic>\u00a0=\u00a01352). Logistic regression was used to calculate odds ratios (ORs), with A\u03b2\u2010PET positivity as the standard\u2010of\u2010truth.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Following adjustment, WMHs (OR\u00a0=\u00a01.25) and superficial CMBs (OR\u00a0=\u00a01.45) remained positively associated with A\u03b2\u2010PET positivity (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Deep CMBs and lacunes exhibited a varied relationship with A\u03b2\u2010PET in cognitive subgroups. The combined diagnostic model, which included CVD biomarkers and other accessible measures, significantly predicted A\u03b2\u2010PET (pseudo\u2010R<jats:sup>2\u00a0<\/jats:sup>=\u00a00.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The study highlights the translational value of CVD biomarkers in diagnosing AD, and underscores the need for more research on their inclusion in diagnostic criteria. <jats:bold>ClinicalTrials.gov<\/jats:bold>: ADNI\u20102 (NCT01231971), ADNI\u20103 (NCT02854033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cerebrovascular biomarkers linked to amyloid beta (A\u03b2) in Alzheimer's disease (AD).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>White matter hyperintensities and cerebral microbleeds reliably predict A\u03b2\u2010PET positivity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Relationships with A\u03b2\u2010PET vary by cognitive stage.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Novel accessible model predicts A\u03b2\u2010PET status.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Study supports multimodal diagnostic approaches.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14207","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T02:10:12Z","timestamp":1725243012000},"page":"7220-7231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-1535","authenticated-orcid":false,"given":"Matthew D.","family":"Howe","sequence":"first","affiliation":[{"name":"Butler Hospital Memory &amp; Aging Program  Providence Rhode Island USA"},{"name":"Department of Psychiatry and Human Behavior Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan R.","family":"Caruso","sequence":"additional","affiliation":[{"name":"Butler Hospital Memory &amp; Aging Program  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood","family":"Manoochehri","sequence":"additional","affiliation":[{"name":"Butler Hospital Memory &amp; Aging Program  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary J.","family":"Kunicki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheina","family":"Emrani","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Center of Innovation in Long\u2010Term Services and Supports, Providence VA Medical Center  Providence Rhode Island USA"},{"name":"Department of Medicine The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Huey","sequence":"additional","affiliation":[{"name":"Butler Hospital Memory &amp; Aging Program  Providence Rhode Island USA"},{"name":"Department of Psychiatry and Human Behavior Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Salloway","sequence":"additional","affiliation":[{"name":"Butler Hospital Memory &amp; Aging Program  Providence Rhode Island USA"},{"name":"Department of Psychiatry and Human Behavior Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwamee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180992"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12366"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101717\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f4d7f8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.01.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.178962"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005439\u2010w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.195511"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.601320"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/380168a0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010019\u20100281\u20102"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(22)00208\u20103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666210212160902"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00072"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102013\u2010306285"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.05.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.06.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010190625"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021539"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026235"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101952"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2005.09.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.10.006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.013"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.109009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010014\u20102753\u20103"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000836\u20101"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.042835"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.11.010"},{"key":"e_1_2_8_34_1","unstructured":"Revised Criteria for Diagnosis and Staging of Alzheimer's. AAIC. Accessed December 4 2023.https:\/\/aaic.alz.org\/diagnostic\u2010criteria.asp"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000285"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.19943"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117173"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0832"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003746"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103383"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13057"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.008"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207378"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.1321"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010191028"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2018.07.019"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010019\u201000118\u20107"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000403\u20103"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12756"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.010"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2016.00864"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30499\u2010X"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010023\u201010122\u20103"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000614"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003184"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14610"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.122975"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13789"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4161"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.96"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.14283\/JPAD.2023.30\/TABLES\/11"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14207","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:41:06Z","timestamp":1759934466000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/alz.14207"],"URL":"https:\/\/doi.org\/10.1002\/alz.14207","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}