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Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Multi\u2010omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA), who are disproportionately affected by AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>To bridge this gap, Accelerating Medicines Partnership in Alzheimer's Disease (AMP\u2010AD) expanded brain multi\u2010omics profiling to multi\u2010ethnic donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We generated multi\u2010omics data and curated and harmonized phenotypic data from BA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0306), LA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0326), or BA and LA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04) brain donors plus non\u2010Hispanic White (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0252) and other (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) ethnic groups, to establish a foundational dataset enriched for BA and LA participants. This study describes the data available to the research community, including\u00a0transcriptome from three brain regions, whole genome sequence, and proteome measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The inclusion of traditionally underrepresented groups in multi\u2010omics studies is essential to discovering the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi\u2010ethnic populations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Brain multi\u2010omics data is generated from Black American, Latin American, and non\u2010Hispanic White donors.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14208","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T02:33:10Z","timestamp":1725071590000},"page":"7174-7192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Bridging the gap: Multi\u2010omics profiling of brain tissue in Alzheimer's disease and older controls in multi\u2010ethnic populations"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-4453","authenticated-orcid":false,"given":"Joseph S.","family":"Reddy","sequence":"first","affiliation":[{"name":"Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Heath","sequence":"additional","affiliation":[{"name":"Sage Bionetworks  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby 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