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Current analyses sought to contrast the cognitive profiles of EOAD and LOAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Z\u2010<\/jats:italic>\n                      score cognitive\u2010domain composites for 311 amyloid\u2010positive sporadic EOAD and 314 amyloid\u2010positive LOAD participants were calculated from baseline data from age\u2010appropriate control cohorts.\n                      <jats:italic>Z\u2010<\/jats:italic>\n                      score composites were compared between AD groups for each domain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>After controlling for cognitive status, EOAD displayed worse visuospatial, executive functioning, and processing speed\/attention skills relative to LOAD, and LOAD displayed worse language, episodic immediate memory, and episodic delayed memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Sporadic EOAD possesses distinct cognitive profiles relative to LOAD. Clinicians should be alert for non\u2010amnestic impairments in younger patients to ensure proper identification and intervention using disease\u2010modifying treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Both early\u2010onset Alzheimer's disease (EOAD) and late\u2010onset Alzheimer's disease (LOAD) participants displayed widespread cognitive impairments relative to their same\u2010aged peers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Cognitive impairments were more severe for EOAD than for LOAD participants in visuospatial and executive domains.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Memory and language impairments were more severe for LOAD than for EOAD participants<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Results were comparable after removing clinical phenotypes of posterior cortical atrophy (PCA), primary progressive aphasia (lv\u2010PPA), and frontal\u2010variant AD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14218","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T04:00:58Z","timestamp":1734926458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Differences in baseline cognitive performance between participants with early\u2010onset and late\u2010onset Alzheimer's disease: Comparison of LEADS and ADNI"],"prefix":"10.1002","volume":"21","author":[{"given":"Dustin B.","family":"Hammers","sequence":"first","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Eloyan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Center for Statistical Sciences Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryanne","family":"Thangarajah","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Center for Statistical Sciences Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Taurone","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Center for Statistical Sciences Brown University  Providence Rhode Island 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