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All analyses were adjusted for age, sex, and cognitive status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Across cohorts, the main biomarker associated with \u03b1\u2010synuclein positivity at baseline was higher levels of A\u03b2 pathology (all\n                      <jats:italic>p<\/jats:italic>\n                      values\u00a0\u2264\u00a00.02), but not tau. Looking at longitudinal measures of AD biomarkers, \u03b1\u2010synuclein \u2013positive participants had a statistically significant faster increase of A\u03b2 load, although of modest magnitude (1.11 Centiloid\/year,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), compared to \u03b1\u2010synuclein \u2013negative participants in BioFINDER\u20102 but not in ADNI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We showed associations between concurrent misfolded \u03b1\u2010synuclein and A\u03b2 levels, providing in vivo evidence of links between these two molecular disease pathways in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights:<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Amyloid beta (A\u03b2), but not tau, was associated with alpha\u2010synuclein (\u03b1\u2010synuclein) positivity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Such association was consistent across two cohorts, beyond the effect of age, sex, and cognitive status.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u03b1\u2010synuclein\u2013positive participants had a small, statistically significant faster increase in A\u03b2 positron emission tomography levels in one of the two cohorts.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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