{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:48:10Z","timestamp":1789678090831,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008494","name":"Vontobel-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022663","name":"M\u00e4xi-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We investigated the interactive associations between amyloid and hypertension on the entorhinal cortex (EC) tau and atrophy and the role of cerebral blood flow (CBF) as a shared mechanism by which amyloid and hypertension contribute to EC tau and regional white matter hyperintensities (WMHs).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We analyzed data from older adults without dementia participating in the Add\u2010Tau study (NCT02958670, <jats:italic>n<\/jats:italic>\u00a0=\u00a0138) or Alzheimer's Disease Neuroimaging Initiative (ADNI) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0523) who had available amyloid\u2010positron emission tomography (PET), tau\u2010PET, fluid\u2010attenuated inversion recovery (FLAIR), and T1\u2010weighted magnetic resonance imaging (MRI). A subsample in both cohorts had available arterial spin labeling (ASL) MRI (Add\u2010Tau: <jats:italic>n<\/jats:italic>\u00a0=\u00a078; ADNI: <jats:italic>n<\/jats:italic>\u00a0=\u00a089).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The detrimental effects of hypertension on AD pathology and EC thickness were more pronounced in the Add\u2010Tau cohort. Increased amyloid burden was associated with decreased occipital gray matter CBF in the ADNI cohort. In both cohorts, lower regional gray matter CBF was associated with higher EC tau and posterior WMH burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Reduced cerebral perfusion may be one common mechanism through which hypertension and amyloid are related to increased EC tau and WMH volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Hypertension is associated with increased entorhinal cortex (EC) tau, particularly in the presence of amyloid.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Decreased cortical cerebral blood flow (CBF) is associated with higher regional white matter hyperintensity volume.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Increasing amyloid burden is associated with decreasing CBF in the occipital lobe.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>MTL CBF and amyloid are synergistically associated with EC tau.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14233","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T08:14:31Z","timestamp":1725956071000},"page":"7729-7744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hypertension and cerebral blood flow in the development of Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-537X","authenticated-orcid":false,"given":"Dario","family":"Bachmann","sequence":"first","affiliation":[{"name":"Institute for Regenerative Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Health Sciences and Technology ETH Z\u00fcrich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Saake","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine University 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