{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:00:14Z","timestamp":1781791214516,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201022\u2010723000"],"award-info":[{"award-number":["AARG\u201022\u2010723000"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Subjective cognitive decline (SCD) may be an early marker of Alzheimer's disease (AD) pathology. Until recently, it was impossible to measure biomarkers specific for \u03b1\u2010synuclein pathology; therefore, its association with subjective reports of cognitive decline is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Alzheimer's Disease Neuroimaging Initiative participants without dementia (<jats:italic>n<\/jats:italic>\u00a0=\u00a0918) were classified as positive or negative for amyloid beta (A\u03b2+ or A\u03b2\u2212) and \u03b1\u2010synuclein (\u03b1\u2010syn+ or \u03b1\u2010syn\u2212) biomarkers. Self\u2010 and study partner\u2013reported cognitive decline was measured with the Everyday Cognition (ECog) questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Per self\u2010report, A\u03b2+\/\u03b1\u2010syn+ had the greatest cognitive decline. A\u03b2\u2212\/\u03b1\u2010syn+ did not differ from A\u03b2\u2212\/\u03b1\u2010syn\u2212 across ECog scores. Study partner\u2013reported results had a similar pattern, but A\u03b2+\/\u03b1\u2010syn\u2212 and A\u03b2+\/\u03b1\u2010syn+ did not differ across ECog scores. Mild cognitive impairment classification moderated the study partner\u2013reported memory score.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>While \u03b1\u2010syn+ alone did not increase subjective reports of cognitive decline, A\u03b2+\/\u03b1\u2010syn+ had the most self\u2010 and study partner\u2013rated cognitive decline. Therefore, the presence of multiple pathologies was associated with greater SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cerebrospinal fluid \u03b1\u2010synuclein (\u03b1\u2010syn) seed amplification assay was used to determine \u03b1\u2010syn positivity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Amyloid beta (A\u03b2)\u2212\/\u03b1\u2010syn\u2212, A\u03b2\u2212\/\u03b1\u2010syn+, A\u03b2+\/\u03b1\u2010syn\u2212, and A\u03b2+\/\u03b1\u2010syn+ biomarker groups were created.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A\u03b2+\/\u03b1\u2010syn+ had greater subjective cognitive decline (SCD) than the other biomarker groups.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A\u03b2\u2212\/\u03b1\u2010syn+ did not differ from A\u03b2\u2212\/\u03b1\u2010syn\u2212 across self\u2010 or study\u2013partner reported SCD scores.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Study partner\u2013reported subjective memory results were largely driven by participants with mild cognitive impairment.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14239","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T10:36:59Z","timestamp":1727087819000},"page":"7777-7787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Self\u2010 and study partner\u2013reported cognitive decline in older adults without dementia: The role of \u03b1\u2010synuclein and amyloid biomarkers in the Alzheimer's Disease Neuroimaging Initiative"],"prefix":"10.1002","volume":"20","author":[{"given":"Kelsey R.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"},{"name":"VA San Diego Healthcare System  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