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The 2024 numeric clinical staging framework, incorporating biomarker staging, was specifically applied to 154 individuals within the Alzheimer's disease (AD) continuum.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The 2024 staging scheme accurately classified 95.5% AD. Among these, 56.5% exhibited concordant clinical and biological stages (canonical), 34.7% demonstrated more advanced clinical stages than biologically expected (susceptible), and 8.8% displayed the inverse pattern (resilient). The susceptible group was characterized by a higher burden of neurodegeneration and inflammation than anticipated from tau, whereas the resilient group showed the opposite.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The 2024 staging scheme is generally feasible. A discrepancy between clinical and biological stages is relatively frequent among symptomatic patients with AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The 2024 AA staging scheme is generally feasible in a tertiary memory clinic.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A discrepancy between clinical and biological stages is relatively frequent in AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The mismatch may be influenced by a non\u2010specific pathological process involved in AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Individual profiles like aging and lifestyles may contribute to such a mismatch.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Matched and mismatched cases converge toward similar clinical outcomes.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14245","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T14:09:31Z","timestamp":1726582171000},"page":"7831-7846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pilot implementation of the revised criteria for staging of Alzheimer's disease by the Alzheimer's Association Workgroup in a tertiary memory clinic"],"prefix":"10.1002","volume":"20","author":[{"given":"Jiaying","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine &amp; 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