{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:39:20Z","timestamp":1787863160699,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We investigated the prevalence of amyloid beta (A\u03b2) positivity (+) and cognitive trajectories in Koreans and non\u2010Hispanic Whites (NHWs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We included 5121 Koreans from multiple centers across South Korea and 929 NHWs from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants underwent A\u03b2 positron emission tomography and were categorized into cognitively unimpaired (CU), mild cognitive impairment (MCI), and dementia stages. Age, sex, education, and\n                      <jats:italic>apolipoprotein E<\/jats:italic>\n                      . genotype were adjusted using multivariable logistic regression and stabilized inverse probability of treatment weights based on the propensity scores to mitigate imbalances in these variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The prevalence of A\u03b2+ was lower in CU Koreans than in CU NHWs (adjusted odds ratio 0.60). A\u03b2+ Koreans showed a faster cognitive decline than A\u03b2+ NHWs in the CU (B\u00a0=\u00a0\u22120.314,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.004) and MCI stages (B\u00a0=\u00a0\u22120.385,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Ethnic characteristics of A\u03b2 biomarkers should be considered in research and clinical application of A\u03b2\u2010targeted therapies in diverse populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Koreans have a lower prevalence of A\u03b2 positivity compared to NHWs in the CU stage.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The effects of Alzheimer's risk factors on A\u03b2 positivity differ between Koreans and NHWs.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A\u03b2\u2010positive (A\u03b2+) Koreans show faster cognitive decline than A\u03b2+ NHWs in the CU and MCI stages.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14247","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T09:37:58Z","timestamp":1727170678000},"page":"7556-7566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ethnic differences in the prevalence of amyloid positivity and cognitive trajectories"],"prefix":"10.1002","volume":"20","author":[{"given":"Hyemin","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Gangnam\u2010gu Seoul South Korea"},{"name":"Department of Neurology Seoul National University Hospital Seoul National University College of Medicine  Jongno\u2010gu Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Gangnam\u2010gu Seoul South Korea"},{"name":"Department of Neurology Yonsei University College of Medicine  Seodaemun\u2010gu Seoul South Korea"},{"name":"Department of Neurology Yongin Severance Hospital Yonsei University Health System  Yongin\u2010si Gyeonggi\u2010do South 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 Guro\u2010gu Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Gangnam\u2010gu Seoul South Korea"},{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Gangnam\u2010gu Seoul South Korea"},{"name":"Department of Health Sciences and Technology SAIHST, Sungkyunkwan University  Seoul South Korea"},{"name":"Department of Digital Health SAIHST, Sungkyunkwan University  Gangnam\u2010gu Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Gangnam\u2010gu Seoul South Korea"},{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Gangnam\u2010gu Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Hyung","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ajou University School of Medicine Ajou University Hospital  Suwon\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Joon","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ajou University School of Medicine Ajou University Hospital  Suwon\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Woong","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ajou University School of Medicine Ajou University Hospital  Suwon\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Kyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Bucheon Hospital  Bucheon\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eek\u2010Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Bucheon Hospital  Bucheon\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Gangnam\u2010gu Seoul South 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