{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:34:21Z","timestamp":1791815661297,"version":"4.3.4"},"reference-count":193,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016608","name":"Rainwater Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The tauopathies are defined by pathological tau protein aggregates within a spectrum of clinically heterogeneous neurodegenerative diseases. The primary tauopathies meet the definition of rare diseases in the United States. There is no approved treatment for primary tauopathies. In this context, designing the most efficient development programs to translate promising targets and treatments from preclinical studies to early\u2010phase clinical trials is vital. In September 2022, the Rainwater Charitable Foundation convened an international expert workshop focused on the translation of tauopathy therapeutics through early\u2010phase trials. Our report on the workshop recommends a framework for principled drug development and a companion lexicon to facilitate communication focusing on reproducibility and achieving common elements. Topics include the selection of targets, drugs, biomarkers, participants, and study designs. The maturation of pharmacodynamic biomarkers to demonstrate target engagement and surrogate disease biomarkers is a crucial unmet need.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Experts provided a framework to translate therapeutics (discovery to clinical trials).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Experts focused on the \u201c5 Rights\u201d (target, drug, biomarker, participants, trial).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Current research on frontotemporal degeneration, progressive supranuclear palsy, and corticobasal syndrome therapeutics includes 32 trials (37% on biologics)<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Tau therapeutics are being tested in Alzheimer's disease; primary tauopathies have a large unmet need.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14250","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T11:35:03Z","timestamp":1727177703000},"page":"8129-8152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A framework for translating tauopathy therapeutics: Drug discovery to clinical trials"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4538","authenticated-orcid":false,"given":"Howard H.","family":"Feldman","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Chambers\u2010Grundy Center for Transformative Neuroscience Department of Brain Health School of Integrated Health Sciences University of Nevada at Las Vegas  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Staffaroni","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Sukoff Rizzo","sequence":"additional","affiliation":[{"name":"Aging Institute University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Territo","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology Harvard Medical School Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Ballard","sequence":"additional","affiliation":[{"name":"College of Medicine and Health University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Beher","sequence":"additional","affiliation":[{"name":"Asceneuron  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny A.","family":"Dacks","sequence":"additional","affiliation":[{"name":"The Association for Frontotemporal Degeneration  King of Prussia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristophe","family":"Diaz","sequence":"additional","affiliation":[{"name":"CurePSP  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Ewen","sequence":"additional","affiliation":[{"name":"UCB Pharma  Slough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Fiske","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Isabel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Consultants  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn A.","family":"Harris","sequence":"additional","affiliation":[{"name":"Rainwater Charitable Foundation  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth J.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Origami Therapeutics  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terina N.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Critical Path Institute  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"McDade","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Nisenbaum","sequence":"additional","affiliation":[{"name":"Alzheimer's Drug Discovery Foundation  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u2010Alberto","family":"Palma","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research  Cambridge Massachusetts USA"},{"name":"Department of Neurology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Quintana","sequence":"additional","affiliation":[{"name":"Berry Consultants  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil D.","family":"Rabinovici","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease Dementia Research Centre Queen Square Institute of Neurology University College of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Troyer","sequence":"additional","affiliation":[{"name":"Denali Therapeutics  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Genetics and Aging Research Unit McCance Center for Brain Health Mass General Institute for Neurodegenerative Disease Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph E.","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Department of Neurology Genetics and Aging Research Unit McCance Center for Brain Health Mass General Institute for Neurodegenerative Disease Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick K.","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Biogen  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"May","sequence":"additional","affiliation":[{"name":"ADvantage Neuroscience Consulting LLC  Fort Wayne Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Rommel","sequence":"additional","affiliation":[{"name":"Rainwater Charitable Foundation  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.4051"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.12.4506"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.03.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00341\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00809"},{"key":"e_1_2_8_7_1","unstructured":"World Health Organization.Dementia.WHO.https:\/\/www.who.int\/health\u2010topics\/dementia#tab=tab_1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000753\u20109"},{"key":"e_1_2_8_9_1","unstructured":"Alzheimer's Association.2022 Alzheimer's Disease Facts and Figures.https:\/\/www.alz.org\/alzheimers\u2010dementia\/facts\u2010figures"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.08.199"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002638"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010018\u20100114\u20108"},{"key":"e_1_2_8_13_1","volume-title":"Rare Diseases: Common Issues in Drug Development Guidance for Industry","author":"U.S. Food and Drug Administration","year":"2019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002326\u20103"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105010"},{"key":"e_1_2_8_16_1","volume-title":"ADRD Summit 2022 Report to the National Advisory Neurological Disorders and Stroke Council","author":"National Institute of Neurological Disorders and Stroke","year":"2022"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.4956"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70223\u20104"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011774"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010181471"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010015\u20100341\u20102"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010019\u20100529\u20105"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102022\u2010329024"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.05.013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.44.12.2308"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010020\u20100397\u20104"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24188"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt244"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_8_33_1","volume-title":"BEST (Biomarkers, EndpointS, and other Tools) Resource","author":"FDA\u2010NIH Biomarker Working Group","year":"2016"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202867"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203395"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209137"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010020\u201000434\u2010z"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007242"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26285"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.21"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802195913"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204705"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916945"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c170002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105532"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2013.00057"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010022\u201010970\u2010x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010022\u201001330\u2010x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.10.004"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.08.001"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010015\u20101509\u2010x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415755"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000653\u20100"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001321\u20107"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.155"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn500143n"},{"key":"e_1_2_8_57_1","unstructured":"Denali Therapeutics.Genetic pathway potential.https:\/\/www.denalitherapeutics.com\/science\/pathway"},{"key":"e_1_2_8_58_1","unstructured":"ALZFORUM.Research Models. Accessed November 4 2022.https:\/\/www.alzforum.org\/research\u2010models\/search?species=&diseases=&genes%5B%5D=33511&types=&keywords\u2010entry=&keywords=tau#results"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1149761"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010021\u201000476\u2010x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101326\u20103\u20108"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12521"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2420"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.09.020"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.06.014"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.034"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592748"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.09.006"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.09.001"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100468\u20103"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.766773"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.042"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv222"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv246"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10821"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.068"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13800"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.05.008"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201002147\u20103"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101541"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161969"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049150"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.003"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u201037620\/v1"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.04.018"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2590\u201020.2021"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1523\u201015.2015"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146127"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.06.022"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201005788\u20100"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00172"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190980"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12417"},{"key":"e_1_2_8_95_1","unstructured":"MODEL\u2010AD: Model Organism Development for Late Onset Alzheimer's Disease. Accessed November 4 2022.https:\/\/model\u2010ad.org"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12110"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12038"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13108"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8255"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz019"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1858"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001309\u20106"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc0655"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau5732"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(17)30157\u20106"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32205\u20104"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.1"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.176"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.046"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad024"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.09.007"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105120"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb2639"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.099"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.101"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001455\u2010x"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30489\u20100"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.3812"},{"key":"e_1_2_8_123_1","article-title":"First cognitive signal that tau immunotherapy works?","author":"Shugart J","year":"2021","journal-title":"ALZFORUM"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.1375"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30139\u20105"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010021\u201002318\u2010y"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00070-2"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010018\u20101911\u20102"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010021\u201001546\u20106"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.061328"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/abt\/tbac028"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134919"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.590896"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.12.012"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.11213"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.63"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.2400"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.266122"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002944\u20101"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101726"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224952"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3861"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100175\u20104"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010021\u201000122\u20107"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102020\u2010324286"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001103\u20107"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1190402"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.6567"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001912\u20100"},{"key":"e_1_2_8_150_1","unstructured":"FDA Converts Novel Alzheimer's Disease Treatment to Traditional Approach.2023. Accessed July 6 2023.https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010converts\u2010novel\u2010alzheimers\u2010disease\u2010treatment\u2010traditional\u2010approval"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbas.2023.100093"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_2_8_153_1","unstructured":"FDA's Decision to Approve New Treatment for Alzheimer's Disease.U.S. Food & Drug Administration;2021. Accessed June 7 2021.https:\/\/www.fda.gov\/drugs\/our\u2010perspective\/fdas\u2010decision\u2010approve\u2010new\u2010treatment\u2010alzheimers\u2010disease"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010022\u201000665\u20102"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010021\u201000541\u20105"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.265930"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010022\u201006087\u2010y"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002075\u20109"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002443\u2010z"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz346"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23002"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003911\u20107"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010018\u20100649\u20103"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.07.007"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1534"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005261"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac310"},{"key":"e_1_2_8_168_1","unstructured":"U.S. Food and Drug Administration.Biomarker Qualification Program. Context of Use.2021.https:\/\/www.fda.gov\/drugs\/biomarker\u2010qualification\u2010program\/context\u2010use"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2013.07.017"},{"key":"e_1_2_8_170_1","unstructured":"The ALLFTD Research Study.The ARTFL\u2010LEFFTDS Longitudinal Frontotemporal Lobar Degeneration Study.https:\/\/www.allftd.org\/"},{"key":"e_1_2_8_171_1","unstructured":"GENFI: Genetic FTD Initiative.https:\/\/www.genfi.org\/"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.4947"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70324\u20102"},{"key":"e_1_2_8_174_1","unstructured":"FTD Preventive Initiative.Boxer Lab University of California San Francisco.2023.https:\/\/boxerlab.ucsf.edu\/study\/fpi"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001942\u20109"},{"key":"e_1_2_8_176_1","volume-title":"Human Gene Therapy for Neurodegenerative Diseases: Guidance for Industry","author":"U.S. Food and Drug Administration","year":"2022"},{"issue":"2","key":"e_1_2_8_177_1","first-page":"119","article-title":"Progressive supranuclear palsy \u2013 parkinsonian disorder with tau pathology","volume":"42","author":"Kowalska A","year":"2004","journal-title":"Folia Neuropathol"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010023\u201002691\u2010w"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.053157"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1080\/13554794.2010.522588"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12423"},{"key":"e_1_2_8_183_1","volume-title":"Patient\u2010Focused Drug Development: Selecting, Developing, or Modifying Fit\u2010for\u2010Purpose Clinical Outcome Assessments","author":"U.S. Food and Drug Administration","year":"2022"},{"key":"e_1_2_8_184_1","first-page":"1","volume-title":"Frontotemporal Degeneration (FTD): A Voice of the Patient Report","author":"Dodge S","year":"2021"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010022\u201000420\u20101"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510062"},{"key":"e_1_2_8_187_1","volume-title":"Adaptive Design Clinical Trials for Drugs and Biologics Guidance for Industry","author":"U.S. Food and Drug Administration. Center for Biologics Evaluation and Research, Center for Drug Evaluation Research","year":"2019"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7811"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.07.005"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001369\u20108"},{"key":"e_1_2_8_191_1","volume-title":"A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN\u2010TU) (DIAN\u2010TU)","author":"Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.09.023"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001015\u20106"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13142\u2010014\u20100265\u20100"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:38:09Z","timestamp":1759934289000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":193,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/alz.14250"],"URL":"https:\/\/doi.org\/10.1002\/alz.14250","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]},"assertion":[{"value":"2024-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}