{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:00:25Z","timestamp":1791914425909,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Not all individuals who experience mild cognitive impairment (MCI) transition through progressive stages of cognitive decline at the same rate, if at all. Previous observational studies have identified the retrosplenial cortex (RSC) as an early site of hypometabolism in MCI which seems to be predictive of later transition to Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We examined <jats:italic>N<\/jats:italic>\u00a0=\u00a0399 MCI subjects with baseline <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography. Subjects were classified based on whether their diagnosis converted from MCI to AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Whole\u2010brain metabolism was decreased in converters (MCI\u2010AD). This effect was more prominent at the RSC, where MCI\u2010AD subjects showed even greater hypometabolism. Observations of RSC hypometabolism and its utility in predicting transition from MCI\u2010AD withstood statistical analyses in a large retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>These results point to the utility of incorporating RSC hypometabolism into predictive models of AD progression risk and call for further examination of mechanisms underlying this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Not all individuals who develop MCI will progress to AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Individuals with MCI who progress to AD show early whole\u2010brain hypometabolism.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Early hypometabolism is particularly prominent at the RSC.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14258","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T07:27:19Z","timestamp":1730186839000},"page":"8979-8986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-0875","authenticated-orcid":false,"given":"Dylan J.","family":"Terstege","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Anatomy Hotchkiss Brain Institute Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa A. 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