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Cognitive differences in groups stratified by FRS and amyloid positivity were assessed at baseline and longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Baseline analyses revealed that amyloid\u2010negative (A\u03b2\u2013) cognitively normal (CN) individuals with high FRS had lower cognition compared to A\u03b2\u2013 CN individuals with low FRS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Longitudinally, amyloid pathology predominantly drove cognitive decline, while FRS alone had negligible effects on cognition in CN and mild cognitive impairment (MCI) groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our findings indicate that managing vascular risk may be crucial in preserving cognition in A\u03b2\u2013 individuals early on and before the clinical manifestation of dementia. Within the CN and MCI groups, irrespective of FRS status, amyloid\u2010positive individuals had worse cognitive performance than A\u03b2\u2013 individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Vascular risk significantly affects cognition in amyloid\u2010negative older Koreans.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid\u2010negative CN older adults with high vascular risk had lower baseline cognition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid pathology drives cognitive decline in CN and MCI, regardless of vascular risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The study underscores the impact of vascular health on the AD disease spectrum.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14290","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:15:24Z","timestamp":1731028524000},"page":"8527-8540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of amyloid and cardiovascular risk with cognition: Findings from KBASE"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8488-6114","authenticated-orcid":false,"given":"Soumilee","family":"Chaudhuri","sequence":"first","affiliation":[{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana 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