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A better understanding of brain structural, perfusion, and functional patterns in the pre\u2010symptomatic stage could inform accurate staging and potential mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We included 207 pre\u2010symptomatic genetic mutation carriers and 188 relatives without mutations. The gray matter volume, cerebral perfusion, and resting\u2010state functional network maps were co\u2010analyzed using linked independent component analysis (LICA). Multiple regression analysis was used to investigate the relationship of LICA components to genetic status and cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Pre\u2010symptomatic mutation carriers showed an age\u2010related decrease in the left frontoparietal network integrity, while non\u2010carriers did not. Executive functions of mutation carriers became dependent on the left frontoparietal network integrity in older age.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The frontoparietal network integrity of pre\u2010symptomatic mutation carriers showed a distinctive relationship to age and cognition compared to non\u2010carriers, suggesting a contribution of the network integrity to brain resilience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>A multimodal analysis of structure, perfusion, and functional networks.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The frontoparietal network integrity decreases with age in pre\u2010symptomatic carriers only.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Executive functions of pre\u2010symptomatic carriers dissociated from non\u2010carriers.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14299","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T06:30:01Z","timestamp":1729146601000},"page":"8576-8594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frontoparietal network integrity supports cognitive function in pre\u2010symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8219-2848","authenticated-orcid":false,"given":"Xulin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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